Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease.

  • -

Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease.

Category : Antiinflamatorio

Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease.

Liver Int. 2018 Jan 17;:

Authors: Adejumo AC, Ajayi TO, Adegbala OM, Adejumo KL, Alliu S, Akinjero AM, Onyeakusi NE, Ojelabi O, Bukong TN

Abstract
BACKGROUND: Abusive alcohol use has well-established health risks including causing liver disease (ALD) characterized by alcoholic steatosis (AS), steatohepatitis (AH), fibrosis, cirrhosis (AC) and hepatocellular carcinoma (HCC). Strikingly, a significant number of individuals who abuse alcohol also use Cannabis, which has seen increased legalization globally. While cannabis has demonstrated anti-inflammatory properties, its combined use with alcohol and the development of liver disease remains unclear.
AIM: To determine the effects of cannabis use on the incidence of liver disease in individuals who abuse alcohol.
METHODS: We analyzed the 2014 Healthcare Cost and Utilization Project – Nationwide Inpatient Sample (NIS) discharge records of patients 18years and older, who had a past or current history of abusive alcohol use(n=319,514). Using the International Classification of Disease, Ninth Edition codes, we studied the four distinct phases of progressive ALD with respect to three cannabis exposure groups: non-cannabis-users (90.39%), non-dependent-cannabis-users (8.26%) and dependent cannabis users (1.36%). We accounted for the complex survey sampling methodology and estimated the adjusted odds ratio (AOR) for developing AS, AH, AC and HCC with respect to cannabis use (SAS 9.4).
RESULTS: Our study revealed that among alcohol users, individuals who additionally use cannabis (dependent and non-dependent cannabis use) showed significantly lower odds of developing AS, AH, AC and HCC (AOR: 0.55[0.48-0.64], 0.57[0.53-0.61], 0.45[0.43-0.48] & 0.62[0.51-0.76]). Further, dependent users had significantly lower odds than non-dependent users for developing liver disease.
CONCLUSIONS: Our findings suggest that cannabis use is associated with reduced incidence of liver disease in alcoholics. This article is protected by copyright. All rights reserved.

PMID: 29341392 [PubMed – as supplied by publisher]

Powered by WPeMatico

Commentarios

comments


Translate »