Evolution of multiple sclerosis spasticity-associated symptoms: latest data.

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Evolution of multiple sclerosis spasticity-associated symptoms: latest data.

Category : Dolor

Evolution of multiple sclerosis spasticity-associated symptoms: latest data.

Neurodegener Dis Manag. 2016 Dec;6(6s):9-12

Authors: Flachenecker P

Abstract
In addition to muscle stiffness and increasing mobility restrictions, symptoms commonly associated with multiple sclerosis (MS) spasticity are spasms, sleep disturbances, pain, fatigue and bladder dysfunction. Treatment options include trigger factor avoidance, physiotherapy and antispasticity medication. Oral antispasticity agents commonly used in Germany are baclofen, tizanidine and gabapentin, but physician and patient satisfaction with their effectiveness is low. Over the past few years, randomized controlled trials, observational studies and registry data have demonstrated the positive risk:benefit profile of add-on 9-delta-tetra-hydrocannabinol:cannabidiol oromucosal spray for moderate-to-severe resistant MS spasticity. Herein, evidence for this novel therapeutic option is reviewed. A case study illustrates the level of improvement in daily functioning that is possible in treatment responders.

PMID: 27874495 [PubMed – in process]

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