Effect of Sativex on spasticity-associated symptoms in patients with multiple sclerosis.

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Effect of Sativex on spasticity-associated symptoms in patients with multiple sclerosis.

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Effect of Sativex on spasticity-associated symptoms in patients with multiple sclerosis.

Expert Rev Neurother. 2015;15(8):909-18

Authors: Meuth SG, Vila C, Dechant KL

Abstract
Individuals with multiple sclerosis (MS) spasticity may experience a range of symptoms, such as bladder dysfunction, pain, impaired sleep quality and mobility restrictions that worsen as spasticity severity increases. In this review, the effects of Sativex(®) oromucosal spray on symptoms and functional impairment associated with MS-related spasticity were examined. Across Sativex studies, there was a clear trend for improvement in spasticity-associated symptoms that was more pronounced and sustained over time in Sativex responders. Meaningful symptomatic improvement was achieved within the recommended dosage limit of ≤12 sprays per day. In appropriate patients, Sativex has the potential to minimize the consequences of spasticity-related symptoms on quality of life and reduce the economic burden on healthcare systems.

PMID: 26166264 [PubMed – indexed for MEDLINE]

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