Role of the lysophosphatidylinositol/GPR55 axis in cancer.

Role of the lysophosphatidylinositol/GPR55 axis in cancer.

Category : Cancer

Role of the lysophosphatidylinositol/GPR55 axis in cancer.

Adv Biol Regul. 2015 Oct 28;

Authors: Falasca M, Ferro R

Abstract
Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumourigenesis. It is well-established that the G protein-coupled receptor 55 (GPR55) is the specific receptor for LPI. Several investigations have demonstrated that the signalling pathways activated by LPI through its receptor GPR55 play a pivotal role in different cancer type. This review focuses on the role of the LPI/GPR55 axis, in particular with regards to its pharmacological potential therapeutic exploitation.

PMID: 26588872 [PubMed – as supplied by publisher]

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