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Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception.

Related Articles Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception. Behav Brain Res. 2017 Sep 18;: Authors: Ellis LD, Berrue F, Morash M, Achenbach JC, Hill J, McDougall JJ Abstract It has been established that both adult and larval zebrafish are capable of showing nociceptive responses to

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Medical marijuana for the treatment of vismodegib-related muscle spasm.

Related Articles Medical marijuana for the treatment of vismodegib-related muscle spasm. JAAD Case Rep. 2017 Sep;3(5):438-440 Authors: Yuan JT, Tello TL, Hultman C, Barker CA, Arron ST, Yom SS PMID: 28932790 [PubMed] Powered by WPeMatico

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[Stress and psychotic transition: A literature review].

Related Articles [Stress and psychotic transition: A literature review]. Encephale. 2016 Aug;42(4):367-73 Authors: Chaumette B, Kebir O, Mam Lam Fook C, Bourgin J, Godsil BP, Gaillard R, Jay TM, Krebs MO Abstract BACKGROUND: Psychiatric disorders are consistent with the gene x environment model, and non-specific environmental factors such as childhood trauma, urbanity, and migration have

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[Delta-9-tetrahydrocannabinol-cannabidiol in the treatment of spasticity in chronic spinal cord injury: a clinical experience].

Related Articles [Delta-9-tetrahydrocannabinol-cannabidiol in the treatment of spasticity in chronic spinal cord injury: a clinical experience]. Rev Neurol. 2017 Oct 01;65(7):295-302 Authors: Grao-Castellote C, Torralba-Collados F, Gonzalez LM, Giner-Pascual M Abstract INTRODUCTION: Spasticity in chronic spinal cord injury is a condition that can have negative repercussions on the patient’s quality of life. Its treatment is

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Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents.

Related Articles Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents. Pharmacotherapy. 2016 Jul;36(7):781-96 Authors: Fasinu PS, Phillips S, ElSohly MA, Walker LA Abstract States and the federal government are under growing pressure to legalize the use of cannabis products for medical purposes in the United States. Sixteen states have legalized (or decriminalized

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Beyond Cannabis: Plants and the Endocannabinoid System.

Related Articles Beyond Cannabis: Plants and the Endocannabinoid System. Trends Pharmacol Sci. 2016 Jul;37(7):594-605 Authors: Russo EB Abstract Plants have been the predominant source of medicines throughout the vast majority of human history, and remain so today outside of industrialized societies. One of the most versatile in terms of its phytochemistry is cannabis, whose investigation

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Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as Adjunctive Therapy in Advanced Cancer Patients With Chronic Uncontrolled Pain.

Related Articles Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as Adjunctive Therapy in Advanced Cancer Patients With Chronic Uncontrolled Pain. J Pain Symptom Manage. 2017 Sep 15;: Authors: Lichtman AH, Lux EA, McQuade R, Rossetti S, Sanchez R, Sun W, Wright S, Kornyeyeva E, Fallon MT Abstract CONTEXT: Prior phase 2/3

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Vicki & Aubrie Hill and Intractable Epilepsy

The story of Aubrey Hill and her mom who moved to California to get reliable access to cannabis oil to treat her intractable epilepsy — with positive results. By Stacey Marie Kerr MD, Hawaiian Ethos Medical Director On September 14, 2017 A patient story with a happy ending A few weeks ago I met Vicki

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Statement on Cannabidiol for the FDA

Project CBD responds to the Food and Drug Administration’s call for statements on the use of CBD. By On September 14, 2017 Sept. 13, 2017 The legal and regulatory status of cannabidiol (CBD), a component of the cannabis plant with a huge therapeutic upside, has emerged as a contentious subject in the United States, even though

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[Cannabis use in Epilepsy. Current situation in Argentina and abroad].

Related Articles [Cannabis use in Epilepsy. Current situation in Argentina and abroad]. Vertex. 2016 Nov;XXVII(130):457-462 Authors: Kochen S Abstract Although at present we have over 20 different types of drugs for epilepsy, 30 to 40% of patients continue to have seizures. Preliminary data from human studies suggest that cannabis, cannabidiol in particular, is effective in

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Cannabidiol, a novel inverse agonist for GPR12.

Related Articles Cannabidiol, a novel inverse agonist for GPR12. Biochem Biophys Res Commun. 2017 Sep 06;: Authors: Brown KJ, Laun AS, Song ZH Abstract GPR12 is a constitutively active, Gs protein-coupled receptor that currently has no confirmed endogenous ligands. GPR12 may be involved in physiological processes such as maintenance of oocyte meiotic arrest and brain

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Cannabis constituent synergy in a mouse neuropathic pain model.

Cannabis constituent synergy in a mouse neuropathic pain model. Pain. 2017 Sep 01;: Authors: Casey SL, Atwal N, Vaughan CW Abstract Cannabis and its psychoactive constituent Δ9-tetrahydrocannabinol (THC) have efficacy against neuropathic pain however, this is hampered by their side-effects. It has been suggested that co-administration with another major constituent cannabidiol (CBD) might enhance the

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Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.

Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain. 2017 Sep 01;: Authors: Philpott HT, O’Brien M, McDougall JJ Abstract Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a non-euphoria producing constituent of cannabis that has the

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A randomised controlled cross-over double-blind pilot study protocol on THC:CBD oromucosal spray efficacy as an add-on therapy for post-stroke spasticity.

A randomised controlled cross-over double-blind pilot study protocol on THC:CBD oromucosal spray efficacy as an add-on therapy for post-stroke spasticity. BMJ Open. 2017 Sep 07;7(9):e016843 Authors: Marinelli L, Balestrino M, Mori L, Puce L, Rosa GM, Giorello L, Currà A, Fattapposta F, Serrati C, Gandolfo C, Abbruzzese G, Trompetto C Abstract INTRODUCTION: Stroke is the

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Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia.

Related Articles Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 03;75:94-105 Authors: Mori MA, Meyer E, Soares LM, Milani H, Guimarães FS, de Oliveira RM Abstract This study investigated the effects of cannabidiol (CBD), a non-psychotomimetic phytochemical present in Cannabis sativa, on the cognitive and

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Gut Check: Does CBD change to THC in the stomach?

Project CBD exposes fraud and financial interests behind misleading report suggesting that CBD converts to THC in the stomach. By Project CBD On February 14, 2017 In 2016, a new journal Cannabis and Cannabinoid Research published a paper suggesting that non-psychoactive cannabidiol (CBD) converts to psychoactive tetrahydrocannabinol (THC) in the stomach. The controversial paper was

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A selective review of medical cannabis in cancer pain management.

Related Articles A selective review of medical cannabis in cancer pain management. Ann Palliat Med. 2017 Aug 23;: Authors: Blake A, Wan BA, Malek L, DeAngelis C, Diaz P, Lao N, Chow E, O’Hearn S Abstract Insufficient management of cancer-associated chronic and neuropathic pain adversely affects patient quality of life. Patients who do not respond

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A Conversion of Oral Cannabidiol to Delta9-Tetrahydrocannabinol Seems Not to Occur in Humans.

Related Articles A Conversion of Oral Cannabidiol to Delta9-Tetrahydrocannabinol Seems Not to Occur in Humans. Cannabis Cannabinoid Res. 2017;2(1):81-86 Authors: Nahler G, Grotenhermen F, Zuardi AW, Crippa JAS Abstract Cannabidiol (CBD), a major cannabinoid of hemp, does not bind to CB1 receptors and is therefore devoid of psychotomimetic properties. Under acidic conditions, CBD can be

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An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.

Related Articles An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis Cannabinoid Res. 2017;2(1):139-154 Authors: Iffland K, Grotenhermen F Abstract Introduction: This literature survey aims to extend the comprehensive survey performed by Bergamaschi et al. in 2011 on cannabidiol (CBD) safety and side effects. Apart

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Cannabis and Pain: A Clinical Review.

Related Articles Cannabis and Pain: A Clinical Review. Cannabis Cannabinoid Res. 2017;2(1):96-104 Authors: Hill KP, Palastro MD, Johnson B, Ditre JW Abstract Introduction: Cannabis has been used for medical purposes across the world for centuries. As states and countries implement medical and recreational cannabis policies, increasing numbers of people are using cannabis pharmacotherapy for pain.

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Training and Practices of Cannabis Dispensary Staff.

Related Articles Training and Practices of Cannabis Dispensary Staff. Cannabis Cannabinoid Res. 2016;1(1):244-251 Authors: Haug NA, Kieschnick D, Sottile JE, Babson KA, Vandrey R, Bonn-Miller MO Abstract Introduction: The proliferation of cannabis dispensaries within the United States has emerged from patient demand for the legalization of cannabis as an alternative treatment for a number of

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Terpene synthases from Cannabis sativa.

Related Articles Terpene synthases from Cannabis sativa. PLoS One. 2017;12(3):e0173911 Authors: Booth JK, Page JE, Bohlmann J Abstract Cannabis (Cannabis sativa) plants produce and accumulate a terpene-rich resin in glandular trichomes, which are abundant on the surface of the female inflorescence. Bouquets of different monoterpenes and sesquiterpenes are important components of cannabis resin as they

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Cannabis Use During Pregnancy: Is it Safe?

Pamela is newly pregnant with her third child. She and her husband think this is going to be their last one because she is having a dreadful time with nausea – morning sickness that lasts all day long. She knows all the tricks. Saltines by her bedside, taking Vitamin B6 and B12, and eating frequently

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The potential role of cannabinoids in epilepsy treatment.

The potential role of cannabinoids in epilepsy treatment. Expert Rev Neurother. 2017 Aug 26;: Authors: De Caro C, Leo A, Citraro R, De Sarro C, Russo R, Calignano A, Russo E Abstract INTRODUCTION: Epilepsy is one of the world’s oldest recognized and prevalent neurological diseases. It has a great negative impact on patients’ quality of

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Cannabinoids as Anticancer Drugs.

Related Articles Cannabinoids as Anticancer Drugs. Adv Pharmacol. 2017;80:397-436 Authors: Ramer R, Hinz B Abstract The endocannabinoid system encompassing cannabinoid receptors, endogenous receptor ligands (endocannabinoids), as well as enzymes conferring the synthesis and degradation of endocannabinoids has emerged as a considerable target for pharmacotherapeutical approaches of numerous diseases. Besides palliative effects of cannabinoids used in

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Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads.

Related Articles Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads. Adv Pharmacol. 2017;80:67-134 Authors: Russo EB, Marcu J Abstract The golden age of cannabis pharmacology began in the 1960s as Raphael Mechoulam and his colleagues in Israel isolated and synthesized cannabidiol, tetrahydrocannabinol, and other phytocannabinoids. Initially, THC garnered most research interest with sporadic

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Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels.

Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels. Epilepsy Behav. 2017 Aug 15;75:29-35 Authors: Vilela LR, Lima IV, Kunsch ÉB, Pinto HPP, de Miranda AS, Vieira ÉLM, de Oliveira ACP, Moraes MFD, Teixeira AL, Moreira FA Abstract Cannabidiol (CBD), the main nonpsychotomimetic compound from Cannabis sativa, inhibits

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GPR55: A therapeutic target for Parkinson’s disease?

Related Articles GPR55: A therapeutic target for Parkinson’s disease? Neuropharmacology. 2017 Aug 11;: Authors: Celorrio M, Rojo-Bustamante E, Fernández-Suárez D, Sáez E, Estella-Hermoso de Mendoza A, Müller CE, Ramírez MJ, Oyarzábal J, Franco R, Aymerich MS Abstract The GPR55 receptor is expressed abundantly in the brain, especially in the striatum, suggesting it might fulfill a

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Antiepileptic drugs in clinical development: differentiate or die?

Related Articles Antiepileptic drugs in clinical development: differentiate or die? Curr Pharm Des. 2017 Aug 09;: Authors: Zaccara G, Schmidt D Abstract BACKGROUND: Animal models when carefully selected, designed and conducted, are important parts of any translational drug development strategy. However, research of new compounds for patients with drug-resistant epilepsies is still based on animal

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Safety profile of the newest antiepileptic drugs: a curated literature review.

Related Articles Safety profile of the newest antiepileptic drugs: a curated literature review. Curr Pharm Des. 2017 Aug 09;: Authors: Palleria C, Cozza G, Khengar R, Libri V, De Sarro G Abstract BACKGROUND: Despite the introduction of new antiepileptic drugs (AEDs), the quality of life and therapeutic response for patients with epilepsy remain unsatisfactory. In

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Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid.

Related Articles Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid. Int J Mol Sci. 2017 Jul 31;18(8): Authors: Kozela E, Juknat A, Vogel Z Abstract The astrocytes have gained in recent decades an enormous interest as a potential target for neurotherapies, due to their essential and pleiotropic roles in brain physiology and pathology. Their

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Evaluation of Oxidant/Antioxidant Status and Cytokine Levels in Patients with Cannabis Use Disorder.

Related Articles Evaluation of Oxidant/Antioxidant Status and Cytokine Levels in Patients with Cannabis Use Disorder. Clin Psychopharmacol Neurosci. 2017 Aug 31;15(3):237-242 Authors: Bayazit H, Selek S, Karababa IF, Cicek E, Aksoy N Abstract Objective: Cannabis is the most commonly used illegal drug in the world and it has several adverse effects such as anxiety, panic

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Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies.

Related Articles Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies. Br J Pain. 2017 Aug;11(3):119-133 Authors: Fallon MT, Albert Lux E, McQuade R, Rossetti S, Sanchez R, Sun W, Wright S, Lichtman AH, Kornyeyeva E Abstract BACKGROUND: Opioids

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Interactions between cannabidiol and commonly used antiepileptic drugs.

Related Articles Interactions between cannabidiol and commonly used antiepileptic drugs. Epilepsia. 2017 Aug 06;: Authors: Gaston TE, Bebin EM, Cutter GR, Liu Y, Szaflarski JP, UAB CBD Program Abstract OBJECTIVE: To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs (AEDs) through an open-label safety study.

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Could Cannabidiol be a Treatment Option for Intractable Childhood and Adolescent Epilepsy?

Related Articles Could Cannabidiol be a Treatment Option for Intractable Childhood and Adolescent Epilepsy? J Epilepsy Res. 2017 Jun;7(1):16-20 Authors: Koo CM, Kang HC Abstract Epilepsy is an important disease that affects brain function, particularly in those under 3 years old. Uncontrolled seizures can affect cognitive function and quality of life. For these reasons, many

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CBD for Fibromyalgia and Opioid Withdrawal

I wanted to relay the experience I’m having with CBD aiding opiate withdrawal. I am a 72-year-old woman. A doctor put me on fentanyl patches about 10 years ago, after trying various painkillers for my intense fibromyalgia pain. They did not notify me how difficult, if not impossible, it would be to get off of

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ICRS 2017: Report from Montreal

During the last week of June, more than 400 scientists from 25 countries met in Montreal for the 27th annual symposium of the International Cannabinoid Research Society (ICRS). Several presentations and posters showcased new findings about cannabidiol (CBD), the non-euphoric component of the cannabis plant that is transforming the medical marijuana landscape. Powered by WPeMatico

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Endocannabinoids in arthritis: current views and perspective.

Related Articles Endocannabinoids in arthritis: current views and perspective. Int J Rheum Dis. 2017 Jul;20(7):789-797 Authors: Barrie N, Kuruppu V, Manolios E, Ali M, Moghaddam M, Manolios N Abstract Preclinical and clinical studies using cannabis-based therapy have been shown to provide both analgesia and anti-inflammatory effects, with an overall alleviation of clinical symptoms in animal

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Effects of antiepileptic drugs on mitochondrial functions, morphology, kinetics, biogenesis, and survival.

Effects of antiepileptic drugs on mitochondrial functions, morphology, kinetics, biogenesis, and survival. Epilepsy Res. 2017 Jul 13;136:5-11 Authors: Finsterer J, Scorza FA Abstract OBJECTIVES: Antiepileptic drugs (AEDs) exhibit adverse and beneficial effects on mitochondria, which have a strong impact on the treatment of patients with a mitochondrial disorder (MID) with epilepsy (mitochondrial epilepsy). This review

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Cannabis: an overview of its adverse acute and chronic effects and their implications.

Cannabis: an overview of its adverse acute and chronic effects and their implications. Curr Drug Abuse Rev. 2017 Jul 12;: Authors: Ford TC, Hayley AC, Downey LA, Parrott AC Abstract In many communities, cannabis is perceived as a low-risk drug, leading to political lobbying to decriminalise its use. However, acute and chronic cannabis use has

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CBD and Parkinson’s Disease

Scientists at the University of Louisville School of Medicine in Kentucky have identified a previously unknown molecular target of cannabidiol (CBD), which may have significant therapeutic implications for Parkinson’s Disease (PD). Powered by WPeMatico

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An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol.

Related Articles An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol. Front Pharmacol. 2017;8:422 Authors: Morales P, Reggio PH, Jagerovic N Abstract Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis. Currently, CBD generates

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Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?

Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients? Expert Opin Ther Targets. 2017 Jul 07;: Authors: Nijs J, Loggia ML, Polli A, Moens M, Huysmans E, Goudman L, Meeus M, Vanderweeën L, Ickmans K, Clauw D Abstract INTRODUCTION: The mechanism of sensitization of the central

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Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats.

Related Articles Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats. Front Pharmacol. 2017;8:391 Authors: Genaro K, Fabris D, Arantes ALF, Zuardi AW, Crippa JAS, Prado WA Abstract Background: Pain involves different brain regions and is critically determined by emotional processing. Among other areas, the rostral anterior cingulate cortex (rACC)

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Suppression of invasion and metastasis in aggressive salivary cancer cells through targeted inhibition of ID1 gene expression.

Related Articles Suppression of invasion and metastasis in aggressive salivary cancer cells through targeted inhibition of ID1 gene expression. Cancer Lett. 2016 Jul 10;377(1):11-6 Authors: Murase R, Sumida T, Kawamura R, Onishi-Ishikawa A, Hamakawa H, McAllister SD, Desprez PY Abstract Salivary gland cancer (SGC) represents the most common malignancy in the head and neck region,

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Marijuana for the Masses

It’s been 50 years since the fabled “Summer of Love” in San Francisco. The City by the Bay was the epicenter of a countercultural uprising fueled by cannabis and LSD, which happened so vividly and with such intensity that it generated worldwide attention. Powered by WPeMatico

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Cannabinoids in Pediatrics.

Related Articles Cannabinoids in Pediatrics. J Pediatr Pharmacol Ther. 2017 May-Jun;22(3):176-185 Authors: Campbell CT, Phillips MS, Manasco K Abstract Despite its controversial nature, the use of medical marijuana and cannabis-derived medicinal products grows more popular with each passing year. As of November 2016, over 40 states have passed legislation regarding the use of either medical

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Assessing the role of serotonergic receptors in cannabidiol’s anticonvulsant efficacy.

Assessing the role of serotonergic receptors in cannabidiol’s anticonvulsant efficacy. Epilepsy Behav. 2017 Jun 15;73:111-118 Authors: Pelz MC, Schoolcraft KD, Larson C, Spring MG, López HH Abstract Cannabidiol (CBD) is a phytocannabinoid that has demonstrated anticonvulsant efficacy in several animal models of seizure. The current experiment validated CBD’s anticonvulsant effect using the acute pentylenetetrazol (PTZ)

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Quality of Life in Childhood Epilepsy in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol.

Quality of Life in Childhood Epilepsy in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol. Epilepsia. 2017 Jun 15;: Authors: Rosenberg EC, Louik J, Conway E, Devinsky O, Friedman D Abstract Recent clinical trials indicate that cannabidiol (CBD) may reduce seizure frequency in pediatric patients with certain forms of treatment-resistant epilepsy. Many

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Project CBD Responds to California’s Proposed Testing Requirements

Our organization outlines our concerns with the State of California’s proposed regulations for cannabis testing regarding pesticides, heavy metals, and solvents and our recommendations for amending them. We believe the following recommendations will benefit patients, recreational users, and people working in the industry. Powered by WPeMatico

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Many Animals Know How to Self-Medicate

Humans aren’t the only species who know how to ingest medicinal plants for their health. Discover the botanical remedies that other animals take, and why they have evolved to do so. Powered by WPeMatico

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Cannabis & Spirituality

The genus Cannabis has been seen and felt as a being, or a deity, in multiple cultures. This book excerpt by Kathleen Harrison discusses some of the historical cultural and spiritual uses of the cannabis plant across the globe. Powered by WPeMatico

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Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways.

Related Articles Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways. Oncotarget. 2017 May 27;: Authors: Ivanov VN, Wu J, Hei TK Abstract Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The challenging problem in cancer treatment is to find

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Cannabis and intractable chronic pain: an explorative retrospective analysis of Italian cohort of 614 patients.

Cannabis and intractable chronic pain: an explorative retrospective analysis of Italian cohort of 614 patients. J Pain Res. 2017;10:1217-1224 Authors: Fanelli G, De Carolis G, Leonardi C, Longobardi A, Sarli E, Allegri M, Schatman ME Abstract BACKGROUND: Despite growing interest in the therapeutic use of cannabis to manage chronic pain, only limited data that address

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Single and combined effects of delta(9) -tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain.

Single and combined effects of delta(9) -tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain. Br J Pharmacol. 2017 May 26;: Authors: King KM, Myers AM, Soroka-Monzo AJ, Tuma RF, Tallarida RJ, Walker EA, Ward SJ Abstract BACKGROUND AND PURPOSE: It has been suggested that the non-psychoactive phytocannabinoid cannabidiol (CBD) can impact the

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Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome.

Related Articles Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome. N Engl J Med. 2017 05 25;376(21):2011-2020 Authors: Devinsky O, Cross JH, Laux L, Marsh E, Miller I, Nabbout R, Scheffer IE, Thiele EA, Wright S, Cannabidiol in Dravet Syndrome Study Group Abstract BACKGROUND: The Dravet syndrome is a complex childhood epilepsy disorder

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Dosing THCA: Less is more

THCA (tetrahydrocannabinolic acid) is the non-psychoactive acid form of THC found in the plant when raw. THCA converts to THC when it is decarboxylated. Discover the clinical and laboratory research on THCA for epilepsy, chronic pain, digestive disorders, and more. Powered by WPeMatico

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Who Is She?

The genus Cannabis has been seen and felt as a being, or a deity, in multiple cultures. This book excerpt by Kathleen Harrison discusses some of the historical cultural and spiritual uses of the cannabis plant across the globe. Powered by WPeMatico

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Cannabidiol in Medical Marijuana: Research Vistas and Potential Opportunities.

Related Articles Cannabidiol in Medical Marijuana: Research Vistas and Potential Opportunities. Pharmacol Res. 2017 May 10;: Authors: Rong C, Lee Y, Carmona NE, Cha DS, Ragguett RM, Rosenblat JD, Mansur RB, Ho RC, McIntyre RS Abstract The high and increasing prevalence of medical marijuana consumption in the general population invites the need for quality evidence

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Cannabidiol in Patients With Intractable Epilepsy Due to TSC: A Possible Medication But Not a Miracle.

Related Articles Cannabidiol in Patients With Intractable Epilepsy Due to TSC: A Possible Medication But Not a Miracle. Epilepsy Curr. 2017 Mar-Apr;17(2):91-92 Authors: Nickels K PMID: 28490996 [PubMed – in process] Powered by WPeMatico

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Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP).

Related Articles Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP). Neurochem Res. 2017 May 06;: Authors: Klein BD, Jacobson CA, Metcalf CS, Smith MD, Wilcox KS, Hampson AJ, Kehne JH Abstract Cannabidiol (CBD) is a cannabinoid component of marijuana that has no significant activity at cannabinoid receptors or psychoactive

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Burning Issue: Cannabis Pesticide Regulations Need Rethink

Pesticide use in the cannabis industry is a widespread issue. Two common pesticides used in marijuana, Eagle 20 and pyrethrins, highlight the inconsistency of current pesticide regulations. Learn why It is paramount to study the effects of heating pesticides and their present and longterm effects.​ Powered by WPeMatico

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Comparative in silico analyses of Cannabis sativa, Prunella vulgaris and Withania somnifera compounds elucidating the medicinal properties against rheumatoid arthritis.

Related Articles Comparative in silico analyses of Cannabis sativa, Prunella vulgaris and Withania somnifera compounds elucidating the medicinal properties against rheumatoid arthritis. J Mol Graph Model. 2017 Apr 19;74:296-304 Authors: Zaka M, Sehgal SA, Shafique S, Abbasi BH Abstract From last decade, there has been progressive improvement in computational drug designing. Several diseases are being

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Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions.

Related Articles Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions. Neuropsychiatr Dis Treat. 2017;13:1131-1140 Authors: Ostendorf AP, Ng YT Abstract Lennox-Gastaut syndrome is a severe, childhood-onset electroclinical syndrome comprised of multiple seizure types, intellectual and behavioral disturbances and characteristic findings on electroencephalogram of slow spike and wave complexes and paroxysmal fast frequency activity. Profound

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Short-Term Efficacy of CBD-Enriched Hemp Oil in Girls with Dysautonomic Syndrome after Human Papillomavirus Vaccination.

Short-Term Efficacy of CBD-Enriched Hemp Oil in Girls with Dysautonomic Syndrome after Human Papillomavirus Vaccination. Isr Med Assoc J. 2017 Feb;19(2):79-84 Authors: Palmieri B, Laurino C, Vadalà M Abstract BACKGROUND: Cannabidiol (CBD)-based treatments for several diseases, including Tourette’s syndrome, multiple sclerosis, epilepsy, movement disorders and glaucoma, are proving to be beneficial and the scientific clinical

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Cannabidiol Treatment for Refractory Seizures in Sturge-Weber Syndrome.

Related Articles Cannabidiol Treatment for Refractory Seizures in Sturge-Weber Syndrome. Pediatr Neurol. 2017 Feb 22;: Authors: Kaplan EH, Offermann EA, Sievers JW, Comi AM Abstract BACKGROUND: Sturge-Weber syndrome results in leptomeningeal vascular malformations, medically refractory epilepsy, stroke(s), and cognitive impairments. Cannabidiol, a cannabinoid without psychoactive properties, has been demonstrated in preclinical models to possibly have

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Cannabidiol-Δ(9)-tetrahydrocannabinol interactions on acute pain and locomotor activity.

Cannabidiol-Δ(9)-tetrahydrocannabinol interactions on acute pain and locomotor activity. Drug Alcohol Depend. 2017 Apr 15;175:187-197 Authors: Britch SC, Wiley JL, Yu Z, Clowers BH, Craft RM Abstract BACKGROUND: Previous studies suggest that cannabidiol (CBD) may potentiate or antagonize Δ(9)-tetrahydrocannabinol’s (THC) effects. The current study examined sex differences in CBD modulation of THC-induced antinociception, hypolocomotion, and metabolism.

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Claws and Effect: Cannabis Medicine for Pets

Any animal with a backbone (classified as a chordate) has an endocannabinoid system. The Kingdom of Chordata includes amphibians, reptiles, birds, fish, and mammals, including house pets. Many animal-owners treat their beloved pets like family members. When a dog or a cat gets sick and conventional options don’t work, people seek alternatives. In the realm

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Neurological aspects of medical use of cannabidiol.

Related Articles Neurological aspects of medical use of cannabidiol. CNS Neurol Disord Drug Targets. 2017 Apr 13;: Authors: Mannucci C, Navarra M, Calapai F, Spagnolo EV, Busardò FP, Da Cas R, Ippolito FM, Calapai G Abstract BACKGROUND: Cannabidiol (CBD) is among the major secondary metabolites of Cannabis devoid of the delta-9-tetra-hydrocannabinol psychoactive effects. It is

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Neuropsychiatric and general interactions of natural and synthetic cannabinoids with drugs of abuse and medicines.

Related Articles Neuropsychiatric and general interactions of natural and synthetic cannabinoids with drugs of abuse and medicines. CNS Neurol Disord Drug Targets. 2017 Apr 13;: Authors: Arellano AL, Papaseit E, Romaguera A, Torrens M, Farré M Abstract Cannabis is the most widely used illicit drug. The two most important natural cannabinoids are delta-9-tetrahydrocannabinol (THC) and

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Anti-neuroinflammatory effects of grossamide from hemp seed via suppression of TLR-4-mediated NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells.

Related Articles Anti-neuroinflammatory effects of grossamide from hemp seed via suppression of TLR-4-mediated NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells. Mol Cell Biochem. 2017 Apr;428(1-2):129-137 Authors: Luo Q, Yan X, Bobrovskaya L, Ji M, Yuan H, Lou H, Fan P Abstract Grossamide, a representative lignanamide in hemp seed, has been reported to possess potential

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Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy.

Related Articles Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy. Neurol Res Int. 2017;2017:2985729 Authors: Aguirre-Velázquez CG Abstract Structured online surveys were used to explore the experiences of the parents of children with refractory epilepsy using medicinal cannabis in Mexico during September 2016. The

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Cannabinoids as hippocampal network administrators.

Related Articles Cannabinoids as hippocampal network administrators. Neuropharmacology. 2017 Apr 06;: Authors: Lupica CR, Hu Y, Devinsky O, Hoffman AF Abstract Extensive pioneering studies performed in the hippocampus have greatly contributed to our knowledge of an endogenous cannabinoid system comprised of the molecular machinery necessary to process these endocannabinoid lipid messengers and their associated cannabinoid

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Cannabidiol Reduces Leukemic Cell Size – But Is It Important?

Related Articles Cannabidiol Reduces Leukemic Cell Size – But Is It Important? Front Pharmacol. 2017;8:144 Authors: Kalenderoglou N, Macpherson T, Wright KL Abstract The anti-cancer effect of the plant-derived cannabinoid, cannabidiol, has been widely demonstrated both in vivo and in vitro. However, this body of preclinical work has not been translated into clinical use. Key

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Update: Toxic Vape Oil Additives Endanger Patients

Vaporizer pens are a trendy and discrete manner to vaporize cannabis medicine. However, commonly used thinning agent in many products on the market are harmful when heated and inhaled. Powered by WPeMatico

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Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy.

Related Articles Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy. Front Pharmacol. 2017;8:131 Authors: Do Val-da Silva RA, Peixoto-Santos JE, Kandratavicius L, De Ross JB, Esteves I, De Martinis BS, Alves MN, Scandiuzzi RC, Hallak JE, Zuardi AW, Crippa JA, Leite JP Abstract The present

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Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn's Disease, a Randomized Controlled Trial.

Related Articles Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn’s Disease, a Randomized Controlled Trial. Dig Dis Sci. 2017 Mar 27;: Authors: Naftali T, Mechulam R, Marii A, Gabay G, Stein A, Bronshtain M, Laish I, Benjaminov F, Konikoff FM Abstract BACKGROUND: Cannabidiol (CBD) is an anti-inflammatory cannabinoid shown to be

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Cannabis, Cannabinoids, and Sleep: a Review of the Literature.

Related Articles Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Curr Psychiatry Rep. 2017 Apr;19(4):23 Authors: Babson KA, Sottile J, Morabito D Abstract PURPOSE OF REVIEW: The current review aims to summarize the state of research on cannabis and sleep up to 2014 and to review in detail the literature on cannabis and specific

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Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?

Related Articles Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids? Front Pharmacol. 2017;8:108 Authors: Brand EJ, Zhao Z Abstract Cannabis sativa L. (Cannabaceae) has a long history of utilization as a fiber and seed crop in China, and its achenes (“seeds”) as well as other plant parts have

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Diet & the Endocannabinoid System

The endocannabinoid system regulates numerous physiological processes, including intestinal function, glucose metabolism, and the stress response. New research discusses the roles of CB1 and CB2 cannabinoid receptors pertaining to diet, digestion, and energy metabolism. Powered by WPeMatico

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Cannabis for Pain and Headaches: Primer.

Related Articles Cannabis for Pain and Headaches: Primer. Curr Pain Headache Rep. 2017 Apr;21(4):19 Authors: Kim PS, Fishman MA Abstract PURPOSE OF REVIEW: Marijuana has been used both medicinally and recreationally since ancient times and interest in its compounds for pain relief has increased in recent years. The identification of our own intrinsic, endocannabinoid system

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Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go?

Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go? Expert Rev Gastroenterol Hepatol. 2017 Feb 16;:1-9 Authors: Hasenoehrl C, Storr M, Schicho R Abstract INTRODUCTION: Fifty years after the discovery of Δ(9)-tetrahydrocannabinol (THC) as the psychoactive component of Cannabis, we are assessing the possibility of translating this herb into clinical

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Cannabinoids therapeutic use: what is our current understanding following the introduction of THC, THC:CBD oromucosal spray and others?

Cannabinoids therapeutic use: what is our current understanding following the introduction of THC, THC:CBD oromucosal spray and others? Expert Rev Clin Pharmacol. 2017 Feb 28;:1-13 Authors: Maccarrone M, Maldonado R, Casas M, Henze T, Centonze D Abstract INTRODUCTION: The complexity of the endocannabinoid (eCB) system is becoming better understood and new drivers of eCB signaling

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The current status of artisanal cannabis for the treatment of epilepsy in the United States.

Related Articles The current status of artisanal cannabis for the treatment of epilepsy in the United States. Epilepsy Behav. 2017 Feb 18;: Authors: Sulak D, Saneto R, Goldstein B Abstract The widespread patient use of artisanal cannabis preparations has preceded quality validation of cannabis use for epilepsy. Neurologists and cannabinoid specialists are increasingly in a

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Potential of Cannabidiol for the Treatment of Viral Hepatitis.

Related Articles Potential of Cannabidiol for the Treatment of Viral Hepatitis. Pharmacognosy Res. 2017 Jan-Mar;9(1):116-118 Authors: Lowe HI, Toyang NJ, McLaughlin W Abstract Viral hepatitis B (HBV) and hepatitis C (HCV) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer. While HBV

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Medical Marijuana for Seizures

A cutting edge paper from three cannabis friendly medical professionals— Dustin Sulak, Russel Saneto, and Bonni Goldstein— outlines case reports and the applications of cannabis medicine for epilepsy and seizure disorders. Powered by WPeMatico

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Related Articles Refractory trigeminal neuralgia responsive to nabiximols in a patient with multiple sclerosis. Mult Scler Relat Disord. 2016 Jul;8:64-5 Authors: Gajofatto A Abstract INTRODUCTION: Nabiximols is a cannabinoid compound approved for the treatment of multiple sclerosis (MS)-related spasticity. However, additional symptoms, such as pain, urinary urgency and sleep disturbance, may benefit from treatment. CASE

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Social correlates of health status, quality of life, and mood states in patients treated with cannabidiol for epilepsy.

Related Articles Social correlates of health status, quality of life, and mood states in patients treated with cannabidiol for epilepsy. Epilepsy Behav. 2017 Feb 21;: Authors: Szaflarski M, Hansen B, Bebin EM, Szaflarski JP Abstract Social characteristics, such as socioeconomic status and race/ethnicity, play a role in the treatment and outcomes of patients with epilepsy

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Chronic low-grade peripheral inflammation is associated with severe nicotine dependence in schizophrenia: results from the national multicentric FACE-SZ cohort.

Chronic low-grade peripheral inflammation is associated with severe nicotine dependence in schizophrenia: results from the national multicentric FACE-SZ cohort. Eur Arch Psychiatry Clin Neurosci. 2017 Feb 25;: Authors: Fond G, Berna F, Andrianarisoa M, Godin O, Leboyer M, Brunel L, Aouizerate B, Capdevielle D, Chereau I, D’Amato T, Denizot H, Dubertret C, Dubreucq J, Faget

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Cannabidiol: State of the art and new challenges for therapeutic applications.

Related Articles Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacol Ther. 2017 Feb 20;: Authors: Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M, Faggiana G, Proto MC, Fiore D, Laezza C, Bifulco M Abstract Over the past years, several lines of evidence support a therapeutic

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Improved Social Interaction, Recognition and Working Memory with Cannabidiol Treatment in a Prenatal Infection (poly I:C) Rat Model.

Related Articles Improved Social Interaction, Recognition and Working Memory with Cannabidiol Treatment in a Prenatal Infection (poly I:C) Rat Model. Neuropsychopharmacology. 2017 Feb 23;: Authors: Osborne AL, Solowij N, Babic I, Huang XF, Weston-Green K Abstract Neuropsychiatric disorders such as schizophrenia are associated with cognitive impairment, including learning, memory and attention deficits. Antipsychotic drugs are

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In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease.

Related Articles In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer’s Disease. Front Pharmacol. 2017;8:20 Authors: Watt G, Karl T Abstract Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that is affecting an increasing number of people. It is characterized by the accumulation of amyloid-β and tau hyperphosphorylation as well as neuroinflammation and

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Cannabis cultivation: Methodological issues for obtaining medical-grade product.

Related Articles Cannabis cultivation: Methodological issues for obtaining medical-grade product. Epilepsy Behav. 2017 Feb 12;: Authors: Chandra S, Lata H, ElSohly MA, Walker LA, Potter D Abstract As studies continue to reveal favorable findings for the use of cannabidiol in the management of childhood epilepsy syndromes and other disorders, best practices for the large-scale production

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Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?

Related Articles Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis? Neural Regen Res. 2016 Dec;11(12):1896-1899 Authors: Giacoppo S, Mazzon E Abstract Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic

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Evaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil by ultra-high performance liquid chromatography tandem mass spectrometry.

Evaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil by ultra-high performance liquid chromatography tandem mass spectrometry. Clin Chem Lab Med. 2017 Feb 16;: Authors: Pacifici R, Marchei E, Salvatore F, Guandalini L, Busardò FP, Pichini S Abstract BACKGROUND: Cannabis has been used since ancient times to relieve neuropathic

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Mind Over Matter Over Mind

The placebo effect happens when an expectation of benefit in a treatment creates the same response as an actual treatment. How does the power of thought influence the endocannabinoid system and our health? Powered by WPeMatico

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Ultra-high performance liquid chromatography tandem mass-spectrometry for simple and simultaneous quantification of cannabinoids.

Related Articles Ultra-high performance liquid chromatography tandem mass-spectrometry for simple and simultaneous quantification of cannabinoids. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Feb 06;1048:10-18 Authors: Jamwal R, Topletz AR, Ramratnam B, Akhlaghi F Abstract Cannabis is used widely in the United States, both recreationally and for medical purposes. Current methods for analysis of

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Cannabidiol: an alternative therapeutic agent for oral mucositis?

Related Articles Cannabidiol: an alternative therapeutic agent for oral mucositis? J Clin Pharm Ther. 2017 Feb 12;: Authors: Cuba LF, Salum FG, Cherubini K, Figueiredo MA Abstract WHAT IS KNOWN AND OBJECTIVE: Chemo- and radiotherapy are therapeutic modalities often used in patients with malignant neoplasms. They kill tumour cells but act on healthy tissues as

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Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection.

Related Articles Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection. Epilepsy Behav. 2017 Feb 09;: Authors: Rosenberg EC, Patra PH, Whalley BJ Abstract The isolation and identification of the discrete plant cannabinoids in marijuana revived interest in analyzing historical therapeutic claims made for cannabis in clinical case studies and

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Treatment issues for children with epilepsy transitioning to adult care.

Treatment issues for children with epilepsy transitioning to adult care. Epilepsy Behav. 2017 Feb 07;: Authors: Nabbout R, Camfield CS, Andrade DM, Arzimanoglou A, Chiron C, Cramer JA, French JA, Kossoff E, Mula M, Camfield PR Abstract This is the third of three papers that summarize the second symposium on Transition in Epilepsies held in

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Cannabinoids in treatment-resistant epilepsy: A review.

Cannabinoids in treatment-resistant epilepsy: A review. Epilepsy Behav. 2017 Feb 07;: Authors: O’Connell BK, Gloss D, Devinsk O Abstract Treatment-resistant epilepsy (TRE) affects 30% of epilepsy patients and is associated with severe morbidity and increased mortality. Cannabis-based therapies have been used to treat epilepsy for millennia, but only in the last few years have we

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The legal status of cannabis (marijuana) and cannabidiol (CBD) under U.S. law.

Related Articles The legal status of cannabis (marijuana) and cannabidiol (CBD) under U.S. law. Epilepsy Behav. 2017 Feb 03;: Authors: Mead A Abstract In the United States, federal and state laws regarding the medical use of cannabis and cannabinoids are in conflict and have led to confusion among patients, caregivers, and healthcare providers. Currently, cannabis

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Complementary Therapies in Inflammatory Bowel Diseases.

Related Articles Complementary Therapies in Inflammatory Bowel Diseases. Curr Gastroenterol Rep. 2016 Dec;18(12):62 Authors: Yanai H, Salomon N, Lahat A Abstract Inflammatory bowel diseases (IBDs) often take a chronic debilitating course. Given the chronicity of IBD, the limitations of the available medications, their potential side effects, and the impact of the disease on patients’ quality

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Mind Over Matter Over Mind: Endocannabinoids & the Placebo Effect

The placebo effect happens when an expectation of benefit in a treatment creates the same response as an actual treatment. How does the power of thought influence the endocannabinoid system and our health? Powered by WPeMatico

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[There is evidence for the use of cannabinoids for symptomatic treatment of multiple sclerosis].

Related Articles [There is evidence for the use of cannabinoids for symptomatic treatment of multiple sclerosis]. Ugeskr Laeger. 2015 May 11;177(20):956-60 Authors: Bazinski H, Jensen HB, Stenager E Abstract We identified 16 randomized placebo-controlled trials investigating cannabinoids as symptomatic treatment in multiple sclerosis (MS). There is evidence that nabiximols oromucosal spray may reduce subjective symptoms

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Phytochemistry of Cannabis sativa L.

Related Articles Phytochemistry of Cannabis sativa L. Prog Chem Org Nat Prod. 2017;103:1-36 Authors: ElSohly MA, Radwan MM, Gul W, Chandra S, Galal A Abstract Cannabis (Cannabis sativa, or hemp) and its constituents-in particular the cannabinoids-have been the focus of extensive chemical and biological research for almost half a century since the discovery of the

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Targeting calcium signaling in cancer therapy.

Related Articles Targeting calcium signaling in cancer therapy. Acta Pharm Sin B. 2017 Jan;7(1):3-17 Authors: Cui C, Merritt R, Fu L, Pan Z Abstract The intracellular calcium ions (Ca(2+)) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca(2+) homeostasis is altered in cancer cells

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Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII).

Related Articles Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII). Epilepsia. 2017 Jan 23;: Authors: Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS Abstract The Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII) took place

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Neuroimaging studies towards understanding the central effects of pharmacological cannabis products on patients with epilepsy.

Related Articles Neuroimaging studies towards understanding the central effects of pharmacological cannabis products on patients with epilepsy. Epilepsy Behav. 2017 Jan 18;: Authors: Allendorfer JB, Szaflarski JP Abstract Recent interest for the use of cannabis-derived products as therapeutic agents in the treatment of epilepsies has necessitated a reevaluation of their effects on brain and behavior.

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Migraine Headaches

While it has been demonstrated that marijuana may help to alleviate migraine headaches, the mechanisms of how it does so is relatively unknown. Dr. Bonni Goldstein highlights current research about the applications for cannabinoid medicine for severe headaches and shares a patient testimony of a mother who found relief from her migraines using THC dominant

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The Society of Cannabis Clinicians critiques AMA guidelines for state medical boards

The Society of Cannabis Clinicians calls on the medical board for more sensible policies towards cannabis, which includes collaboration with medical cannabis dispensaries as well as removing the stigma of cannabis as a substance of abuse. Powered by WPeMatico

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Historical perspective on the medical use of cannabis for epilepsy: Ancient times to the 1980s.

Related Articles Historical perspective on the medical use of cannabis for epilepsy: Ancient times to the 1980s. Epilepsy Behav. 2017 Jan 11;: Authors: Friedman D, Sirven JI Abstract There has been a dramatic surge in the interest of utilizing cannabis for epilepsy treatment in the US. Yet, access to cannabis for research and therapy is

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Cannabidiol Claims and Misconceptions.

Related Articles Cannabidiol Claims and Misconceptions. Trends Pharmacol Sci. 2017 Jan 11;: Authors: Russo EB Abstract Once a widely ignored phytocannabinoid, cannabidiol now attracts great therapeutic interest, especially in epilepsy and cancer. As with many rising trends, various myths and misconceptions have accompanied this heightened public interest and intrigue. This forum article examines and attempts

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Pharmacology of cannabinoids in the treatment of epilepsy.

Related Articles Pharmacology of cannabinoids in the treatment of epilepsy. Epilepsy Behav. 2017 Jan 10;: Authors: Gaston TE, Friedman D Abstract The use of cannabis products in the treatment of epilepsy has long been of interest to researchers and clinicians alike; however, until recently very little published data were available to support its use. This

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Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers.

Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers. Drug Alcohol Depend. 2016 Dec 14;172:9-13 Authors: Babalonis S, Haney M, Malcolm RJ, Lofwall MR, Votaw VR, Sparenborg S, Walsh SL Abstract BACKGROUND: Cannabidiol (CBD) is a naturally occurring constituent of the marijuana plant. In the past few years, there has

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Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review.

Related Articles Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review. Inflamm Bowel Dis. 2017 Jan 10;: Authors: Leinwand KL, Gerich ME, Hoffenberg EJ, Collins CB Abstract BACKGROUND: Inflammatory bowel disease (IBD) is a lifelong disease of the gastrointestinal tract whose annual incidence and prevalence is on the rise. Current immunosuppressive therapies available for

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A user's guide to cannabinoid therapies in oncology.

Related Articles A user’s guide to cannabinoid therapies in oncology. Curr Oncol. 2016 Dec;23(6):398-406 Authors: Maida V, Daeninck PJ Abstract “Cannabinoid” is the collective term for a group of chemical compounds that either are derived from the Cannabis plant, are synthetic analogues, or occur endogenously. Although cannabinoids interact mostly at the level of the currently

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Weed Power: Milk Thistle, Liver Disease & the Endocannabinoid System

Both milk thistle and cannabis convey therapeutic benefits that are mediated by the endocannabinoid system. The active component in milk thistle, silymarin, is responsible for its liver protective qualities and influence both CB1 and CB2 receptors throughout the body. Powered by WPeMatico

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CBD Eye Drops

Cannabis has been well known to treat eye pressure associated with glaucoma. Now new research indicates that direct topical application of cannabidiol (CBD) may be beneficial for neuropathic ocular pain. Powered by WPeMatico

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Therapeutic Use of Cannabis in Inflammatory Bowel Disease.

Related Articles Therapeutic Use of Cannabis in Inflammatory Bowel Disease. Gastroenterol Hepatol (N Y). 2016 Nov;12(11):668-679 Authors: Ahmed W, Katz S Abstract The marijuana plant Cannabis sativa and its derivatives, cannabinoids, have grown increasingly popular as a potential therapy for inflammatory bowel disease (IBD). Studies have shown that modulation of the endocannabinoid system, which regulates

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A Neuroscientist critiques New York Times report on synthetic “spice” cannabinoid

The street popularity of synthetic cannabinoid products such as “Spice” and others have caused problems for users. None of the naturally occurring cannabinoids from the marijuana plant have evolved to be full agonists of the cannabinoid receptors. Dr. Greg Gerdeman weighs in on how synthetic cannabinoid products are a result of cannabis prohibition. Powered by

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Cannabis and epilepsy: An ancient treatment returns to the fore.

Related Articles Cannabis and epilepsy: An ancient treatment returns to the fore. Epilepsy Behav. 2016 Dec 15;: Authors: Russo EB Abstract Cannabis has been associated with the treatment of epilepsy throughout history, and if ancient Assyrian sources referring to “hand of ghost” are considered credible, this relationship may span four millennia. A tradition of usage

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Inhibition of cervical cancer cell proliferation by cannabidiol.

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The DEA Bursts the CBD Bubble

In December of 2016, the DEA announced that it is implementing new rules designed to crack down on CBD oil products. Mass misinformation claiming cannabidiol was legal was promoted by numerous online businesses and their enabling attorneys. Educate yourself about the situation and what you can do. Powered by WPeMatico

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Cannabidiol oil in the treatment of super refractory status epilepticus. A case report.

Related Articles Cannabidiol oil in the treatment of super refractory status epilepticus. A case report. Seizure. 2016 Feb;35:56-8 Authors: Rosemergy I, Adler J, Psirides A PMID: 26803051 [PubMed – indexed for MEDLINE] Powered by WPeMatico

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Mitochondria Mysteries

Scientific data indicates that CBD & THC can affect mitochondria, the energy adaptors that power every multicellular organism. How do cannabinoids influence cellular function? Powered by WPeMatico

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Cannabinoids and Oxidation

Nishi Whiteley discusses the theme of cannabinoids and oxidation from her book “Chronic Relief: A Guide to Cannabis for the Terminally & Chronically Ill”. In the same way that paint protects metal from rusting or lemon juice protects apples from turning brown, cannabinoids protect our cells from oxidation. Powered by WPeMatico

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A systematic review of the effect of cannabidiol on cognitive function: Relevance to schizophrenia.

A systematic review of the effect of cannabidiol on cognitive function: Relevance to schizophrenia. Neurosci Biobehav Rev. 2016 Nov 21;: Authors: Osborne AL, Solowij N, Weston-Green K Abstract BACKGROUND AND OBJECTIVES: Cognitive impairment is a core symptom domain of schizophrenia, neurological disorders and substance abuse. It is characterised by deficits in learning, memory, attention and

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Evolution of multiple sclerosis spasticity-associated symptoms: latest data.

Evolution of multiple sclerosis spasticity-associated symptoms: latest data. Neurodegener Dis Manag. 2016 Dec;6(6s):9-12 Authors: Flachenecker P Abstract In addition to muscle stiffness and increasing mobility restrictions, symptoms commonly associated with multiple sclerosis (MS) spasticity are spasms, sleep disturbances, pain, fatigue and bladder dysfunction. Treatment options include trigger factor avoidance, physiotherapy and antispasticity medication. Oral antispasticity

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Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients.

Related Articles Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients. Epilepsia. 2016 Nov 18;: Authors: Treat L, Chapman KE, Colborn KL, Knupp KG Abstract OBJECTIVE: Oral cannabis extracts (OCEs) are being used in the treatment of epilepsy with increasing rates in the United States following product legalization; however, no

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Cannabidiol Mellows Out Resurgent Sodium Current.

Related Articles Cannabidiol Mellows Out Resurgent Sodium Current. Epilepsy Curr. 2016 Nov-Dec;16(6):399-401 Authors: Thompson CH, Kearney JA PMID: 27857623 [PubMed – in process] Powered by WPeMatico

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Medical Cannabis – another piece in the mosaic of autoimmunity?

Related Articles Medical Cannabis – another piece in the mosaic of autoimmunity? Clin Pharmacol Ther. 2016 Nov 10;: Authors: Katz D, Katz I, Porat-Katz BS, Shoenfeld Y Abstract Legalization of cannabis’ medicinal use is rapidly increasing worldwide, raising the need to evaluate medical implications of cannabis. Currently evidence supports cannabis and its active ingredients as

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Cannabinoid Buccal Spray for Chronic Non-Cancer or Neuropathic Pain: A Review of Clinical Effectiveness, Safety, and Guidelines

Related Articles Cannabinoid Buccal Spray for Chronic Non-Cancer or Neuropathic Pain: A Review of Clinical Effectiveness, Safety, and Guidelines Book. 2016 09 21 Authors: Abstract Chronic pain is a complex, severe and debilitating condition which can lead to a considerable reduction in function and quality of life. Patients may present with different forms of chronic

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Quantitative analyses of synergistic responses between cannabidiol and DNA-damaging agents on the proliferation and viability of glioblastoma and neural progenitor cells in culture.

Related Articles Quantitative analyses of synergistic responses between cannabidiol and DNA-damaging agents on the proliferation and viability of glioblastoma and neural progenitor cells in culture. J Pharmacol Exp Ther. 2016 Nov 7;: Authors: Deng L, Ng L, Ozawa T, Stella N Abstract Evidence suggests that the non-psychotropic cannabis-derived compound, cannabidiol (CBD), has anti-neoplastic activity in

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Targeting the Endocannabinoid System in Psychiatric Illness.

Related Articles Targeting the Endocannabinoid System in Psychiatric Illness. J Clin Psychopharmacol. 2016 Dec;36(6):691-703 Authors: Katzman MA, Furtado M, Anand L Abstract Prevalence of psychiatric disorders continues to rise globally, yet remission rates and patient outcome remain less than ideal. As a result, novel treatment approaches for these disorders are necessary to decrease societal economic

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Patient Survey: Cannabis in the Treatment of Age-Related Pain

A patient survey collaboration between Care by Design and Project CBD demonstrated that cannabis appears to be an effective pain management tool with few negative side effects. The study also found that a significant decrease in opiate usage among elderly patients while taking medical cannabis. Powered by WPeMatico

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Efficacy and safety of nabiximols (Sativex(®)) on multiple sclerosis spasticity in a real-life Italian monocentric study.

Related Articles Efficacy and safety of nabiximols (Sativex(®)) on multiple sclerosis spasticity in a real-life Italian monocentric study. Neurol Sci. 2016 Feb;37(2):235-42 Authors: Ferrè L, Nuara A, Pavan G, Radaelli M, Moiola L, Rodegher M, Colombo B, Keller Sarmiento IJ, Martinelli V, Leocani L, Martinelli Boneschi F, Comi G, Esposito F Abstract Multiple sclerosis (MS)

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Splendor in the Grass? A Pilot Study Assessing the Impact of Medical Marijuana on Executive Function.

Related Articles Splendor in the Grass? A Pilot Study Assessing the Impact of Medical Marijuana on Executive Function. Front Pharmacol. 2016;7:355 Authors: Gruber SA, Sagar KA, Dahlgren MK, Racine MT, Smith RT, Lukas SE Abstract Currently, 25 states and Washington DC have enacted full medical marijuana (MMJ) programs while 18 states allow limited access to

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PROPIEDADES DEL USO TÓPICO DEL ACEITE DE CÁÑAMO Y OTROS ACEITES DE USO MEDICINAL

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Introducción Existen plantas que han acompañado al Hombre desde el principio de los tiempos al destacar por sus múltiples propiedades medicinales, y en un principio, han sido consideradas casi mágicas. La cannabis, por su ubicuidad y multitud de usos, ha sido una de las principales consideradas como tal,  en numerosas culturas desde hace muchos años.

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Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration.

Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Oct 18;: Authors: Nabissi M, Morelli MB, Offidani M, Amantini C, Gentili S, Soriani A, Cardinali C, Leoni P, Santoni G Abstract Several studies showed a potential anti-tumor role for cannabinoids, by modulating cell signaling pathways involved in cancer cell proliferation, chemo-resistance

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Effect of cannabis smoking on lung function and respiratory symptoms: a structured literature review.

Effect of cannabis smoking on lung function and respiratory symptoms: a structured literature review. NPJ Prim Care Respir Med. 2016 Oct 20;26:16071 Authors: Ribeiro LI, Ind PW Abstract As cannabis use increases, physicians need to be familiar with the effects of both cannabis and tobacco on the lungs. However, there have been very few long-term

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Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes.

Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes. Clin Hemorheol Microcirc. 2016 Oct 18; Authors: Lehmann C, Fisher NB, Tugwell B, Szczesniak A, Kelly M, Zhou J Abstract BACKGROUND: Destruction of the insulin-producing beta cells in type 1 diabetes (T1D) is induced by invasion of immune cells causing pancreatic inflammation. Cannabidiol (CBD), a phytocannabinoid,

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Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol.

Related Articles Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol. Front Pharmacol. 2016;7:359 Authors: Crippa JA, Crippa AC, Hallak JE, Martín-Santos R, Zuardi AW Abstract Animal studies and preliminary clinical trials have shown that cannabidiol (CBD)-enriched extracts may have beneficial effects for children with

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Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats.

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Tetrahydrocannabinol:Cannabidiol Oromucosal Spray for Multiple Sclerosis-Related Resistant Spasticity in Daily Practice.

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pain in Extrapyramidal Neurodegenerative Diseases.

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Gastric acid inhibitory and gastric protective effects of Cannabis and cannabinoids.

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Cannabidiol: a potential treatment for post Ebola Syndrome?

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Medical Marijuana: Just the Beginning of a Long, Strange Trip?

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Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Cisplatin-Induced Neuropathy in Mice.

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Phyto-, endo- and synthetic cannabinoids: promising chemotherapeutic agents in the treatment of breast and prostate carcinomas.

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Evaluation of Two Commercially Available Cannabidiol Formulations for Use in Electronic Cigarettes.

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Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells.

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Cannabinoids for Symptom Management and Cancer Therapy: The Evidence.

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ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice.

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Is Kratom the CBD of Opioids?

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I’m Just Mad About Saffron

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Cannabis as Medicine Has Strong Roots in Science

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CBD User's Manual

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Investigación con Cannabinoides en Cáncer de Mama

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El cáncer de mama es uno de los tipos de cáncer más diagnosticados a mujeres en el mundo, según datos del National Cancer Institute. Durante el año 2015, se diagnosticaron aproximadamente unos 246.660  casos de cáncer de mama invasivo a mujeres, y cáncer de mama in situ a 61,000 mujeres en los Estados Unidos. En

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Cannabinoides y enfermedades neurodegenerativas: ¿una futura terapia?

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La enfermedad de Alzheimer es un proceso neurodegenerativo de causa desconocida, que suele aparecer alrededor de los 65 años (aunque puede aparecer antes), en el que se observan cambios neurológicos asociados a la aparición de placas amoloideas y ovillos neurofibrilares, con la consecuente pérdida de las conexiones neuronales. Todo ello provoca un deterioro progresivo de

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CANNABIDIOL: POTENCIAL TERAPÉUTICO PARA EL TRATAMIENTO DE LA ARTRITIS

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Se entiende por artritis a las diferentes enfermedades que cursan con inflamación de las articulaciones, es decir, del área de unión de dos huesos. Se conocen más de 100 tipos de artritis diferentes, aunque todas ellas presentan una característica común: la inflamación de la articulación, que conlleva a una degradación del cartílago que la protege.

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Targeted Treatment in Childhood Epilepsy Syndromes.

Targeted Treatment in Childhood Epilepsy Syndromes. Curr Treat Options Neurol. 2016 Jun;18(6):29 Authors: Vezyroglou K, Cross JH Abstract OPINION STATEMENT: The mainstay of treatment of epilepsy has been antiepileptic drugs; however, despite the emergence of new agents, a consistent proportion remain drug-resistant. Newer AEDs show promise. However, as it becomes clear that the epilepsies are

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Pediatric Concerns Due to Expanded Cannabis Use: Unintended Consequences of Legalization.

Related Articles Pediatric Concerns Due to Expanded Cannabis Use: Unintended Consequences of Legalization. J Med Toxicol. 2016 May 2; Authors: Wang GS Abstract An “unintended consequence” of marijuana legalization is the impact on the pediatric population. From prenatal exposure to unintentional childhood exposures, through concerns of adolescence abuse and marijuana use for medicinal indications in

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Marijuana Not Monoculture!

Companion planting is a method of cultivation where plants are grown together to promote a dynamic, flourishing ecosystem. Some cannabis cultivators have begun adopting these practices, resulting in multiple benefits. Learn more about this concept and how to integrate companion plants into your cannabis grow. Powered by WPeMatico

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Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulata, and fear-induced antinociception elicited by bicuculline administration in deep layers of the superior colliculus: The role of CB1-cannabinoid receptor in the ventral mesencephalon.

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Potential use of Magnolia officinalis bark polyphenols in the treatment of cannabis dependence.

Related Articles Potential use of Magnolia officinalis bark polyphenols in the treatment of cannabis dependence. Med Hypotheses. 2014 Dec;83(6):673-6 Authors: Coppola M, Mondola R Abstract In recent years, epidemiological data confirm that cannabis-related emergencies, cannabis-use disorders and dependence are significantly increased. Cannabis is generally considered a little dangerous substances of abuse, however, chronic consumption has

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ENDOCANNABINOID SYSTEM: A multi-facet therapeutic target.

ENDOCANNABINOID SYSTEM: A multi-facet therapeutic target. Curr Clin Pharmacol. 2016 Apr 17; Authors: Kaur R, Ambwani SR, Singh S Abstract Cannabis sativa is also popularly known as marijuana. It is being cultivated and used by man for recreational and medicinal purposes from many centuries. Study of cannabinoids was at bay for very long time and

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Effect of Sativex on spasticity-associated symptoms in patients with multiple sclerosis.

Related Articles Effect of Sativex on spasticity-associated symptoms in patients with multiple sclerosis. Expert Rev Neurother. 2015;15(8):909-18 Authors: Meuth SG, Vila C, Dechant KL Abstract Individuals with multiple sclerosis (MS) spasticity may experience a range of symptoms, such as bladder dysfunction, pain, impaired sleep quality and mobility restrictions that worsen as spasticity severity increases. In

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Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome.

Related Articles Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome. Pharmacol Res Perspect. 2016 Apr;4(2):e00220 Authors: Rubio M, Valdeolivas S, Piscitelli F, Verde R, Satta V, Barroso E, Montolio M, Aras LM, Di Marzo V, Sagredo O, Fernández-Ruiz J Abstract Cannabidiol (CBD) reduces seizures in childhood epilepsy syndromes

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GanJahnetics Introduces Jamaican Lion CBD-rich Seeds

Some good news for admirers of the first CBD-rich cultivars discovered in California: The breeder of the infamous Jamaican Lion strain is releasing a seed line called GanJahnetics. Now the offspring of CBD-rich Jamaican Lion will now be available for those who want to grow their own. Powered by WPeMatico

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Kristin Nevedal on Cannabis Farming and Pesticides

Kristin Nevedal gives insight on pesticide use in cannabis cultivation. She explains the current landscape of pesticides regulation, pest management, and the need for further research. Powered by WPeMatico

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Marijuana-derived Δ-9-tetrahydrocannabinol suppresses Th1/Th17 cell-mediated delayed-type hypersensitivity through microRNA regulation.

Related Articles Marijuana-derived Δ-9-tetrahydrocannabinol suppresses Th1/Th17 cell-mediated delayed-type hypersensitivity through microRNA regulation. J Mol Med (Berl). 2016 Apr 1; Authors: Sido JM, Jackson AR, Nagarkatti PS, Nagarkatti M Abstract ∆(9)-Tetrahydrocannabinol (THC) is one of the major bioactive cannabinoids derived from the Cannabis sativa plant and is known for its anti-inflammatory properties. Delayed-type hypersensitivity (DTH) is

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In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma.

Related Articles In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma. Curr Oncol. 2016 Mar;23(2):S15-22 Authors: Fisher T, Golan H, Schiby G, PriChen S, Smoum R, Moshe I, Peshes-Yaloz N, Castiel A, Waldman D, Gallily R, Mechoulam R, Toren A Abstract BACKGROUND: Neuroblastoma (nbl) is one of the most common solid cancers in

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Techniques and technologies for the bioanalysis of Sativex(®), metabolites and related compounds.

Techniques and technologies for the bioanalysis of Sativex(®), metabolites and related compounds. Bioanalysis. 2016 Mar 23; Authors: Molnar A, Fu S Abstract Sativex(®) is an oromucosal spray indicated for the treatment of moderate-to-severe spasticity in multiple sclerosis and is also an effective analgesic for advanced cancer patients. Sativex contains Δ(9)-tetrahydrocannabinol (THC) and cannabidiol in an

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Jahan Marcu: Cannabis Lab Testing & Safety Protocols [VIDEO]

Jahan Marcu, lead auditor for ASA’s Patient-Focused Certification program, discusses lab testing, safety protocols, adverse events reporting, and regulatory standards for the cannabis industry. Powered by WPeMatico

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Cannabidiol and epilepsy: rationale and therapeutic potential.

Cannabidiol and epilepsy: rationale and therapeutic potential. Pharmacol Res. 2016 Mar 11; Authors: Leo A, Russo E, Elia M Abstract Despite the introduction of new antiepileptic drugs (AEDs), the quality of life and therapeutic response for patients with epilepsy remains still poor. Unfortunately, besides several advantages, these new AEDs have not satisfactorily reduced the number

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Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients.

Related Articles Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Complement Ther Med. 2015 Oct;23(5):652-7 Authors: Rezapour-Firouzi S, Arefhosseini SR, Ebrahimi-Mamaghani M, Baradaran B, Sadeghihokmabad E, Mostafaei S, Torbati M, Chehreh M Abstract BACKGROUND: The effect of nutrition and dietary

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A urinary test procedure for identification of cannabidiol in patients undergoing medical therapy with marijuana.

A urinary test procedure for identification of cannabidiol in patients undergoing medical therapy with marijuana. J Pain Res. 2016;9:81-5 Authors: Wertlake PT, Henson MD Abstract Marijuana is classified by the Drug Enforcement Agency (DEA) as Schedule I, drugs having no accepted medical value. Twenty-three states and the District of Columbia have legalized medical marijuana. This

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A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain.

Related Articles A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain. J Pain Symptom Manage. 2014 Jan;47(1):166-73 Authors: Lynch ME, Cesar-Rittenberg P, Hohmann AG Abstract CONTEXT: Neuropathic pain caused by chemotherapy limits dosing and duration of potentially life-saving anti-cancer treatment and impairs quality of

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Cannabinoids: Medical implications.

Cannabinoids: Medical implications. Ann Med. 2016 Feb 25;:1-14 Authors: Schrot RJ, Hubbard JR Abstract Herbal cannabis has been used for thousands of years for medical purposes. With elucidation of the chemical structures of tetrahydrocannabinol (THC) and cannabidiol (CBD) and with discovery of the human endocannabinoid system, the medical usefulness of cannabinoids has been more intensively

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Pharmacokinetics of Cannabis in Cancer Cachexia-Anorexia Syndrome.

Related Articles Pharmacokinetics of Cannabis in Cancer Cachexia-Anorexia Syndrome. Clin Pharmacokinet. 2016 Feb 16; Authors: Reuter SE, Martin JH Abstract Anorexia can affect up to 90 % of people with advanced cancer. It is a complex symptom associated with changes in taste, lack of hunger at mealtimes and lack of food enjoyment. Associated weight loss is

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Robert Clarke: Cannabis Botany & Evolution [VIDEO]

Robert Clarke, co-author of Cannabis: Evolution and Ethnobotany, discusses CBD-rich drug plants, disappearing landrace strains, and the future of cannabis farming in the United States. Powered by WPeMatico

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REVISIÓN DE EXPERTOS DE 60 ESTUDIOS SOBRE MARIHUANA MEDICINAL (PARTE II)

Segunda parte de la TRADUCCIÓN  DE UNA REVISIÓN DE EXPERTOS REALIZADA POR ProCon.org*, publicada en su página web el 27/02/2015, en cuanto a estudios médicos relacionados con cannabis y extractos de cannabis se refiere, realizados entre 1990 y 2014. Fuente original: http://medicalmarijuana.procon.org/view.resource.php?resourceID=000884 ESCLEROSIS MÚLTIPLE 1. FAVORABLE. Sativex reduce la espasticidad en la Esclerosis Múltiple (2014)

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Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine.

Related Articles Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine. Mediators Inflamm. 2015;2015:523418 Authors: Vilela LR, Gomides LF, David BA, Antunes MM, Diniz AB, Moreira Fde A, Menezes GB Abstract Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most severe and common complications are seizures, ischemic strokes,

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REVISIÓN DE EXPERTOS DE 60 ESTUDIOS SOBRE MARIHUANA MEDICINAL (PARTE I)

                                           TRADUCCIÓN LITERAL DE UNA REVISIÓN DE EXPERTOS, realizada por ProCon.org*, publicada en su página web el 27/02/2015, en cuanto a estudios médicos relacionados con cannabis y extractos de cannabis se refiere, realizados entre 1990 y

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Medicinal cannabis.

Related Articles Medicinal cannabis. Aust Prescr. 2015 Dec;38(6):212-5 Authors: Murnion B Abstract A number of therapeutic uses of cannabis and its derivatives have been postulated from preclinical investigations. Possible clinical indications include spasticity and pain in multiple sclerosis, cancer-associated nausea and vomiting, cancer pain and HIV neuropathy. However, evidence is limited, may reflect subjective rather

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[Efficacy, tolerability and safety of cannabinoids for chronic neuropathic pain : A systematic review of randomized controlled studies].

Related Articles [Efficacy, tolerability and safety of cannabinoids for chronic neuropathic pain : A systematic review of randomized controlled studies]. Schmerz. 2016 Feb 1; Authors: Petzke F, Enax-Krumova EK, Häuser W Abstract BACKGROUND: Recently published systematic reviews came to different conclusions with respect to the efficacy, tolerability and safety of cannabinoids for treatment of chronic

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Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells.

Related Articles Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37 Authors: Scott KA, Dennis JL, Dalgleish AG, Liu WM Abstract Cannabinoids possess a number of characteristics that make them putative anticancer drugs, and their value as such is currently being explored in a number

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Cannabinoids for pediatric epilepsy? Up in smoke or real science?

Related Articles Cannabinoids for pediatric epilepsy? Up in smoke or real science? Transl Pediatr. 2015 Oct;4(4):271-82 Authors: Filloux FM Abstract Public interest in the use of “medical marijuana” for the treatment of childhood epilepsy has burgeoned in the last few years. This has occurred in parallel with a growing interest in “medical marijuana” in general.

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[Assessment of the effectiveness and safety of Sativex® in compassionate use].

Related Articles [Assessment of the effectiveness and safety of Sativex® in compassionate use]. Rev Neurol. 2015 Mar 1;60(5):202-6 Authors: Cimas-Hernando I, Pato-Pato A, Lorenzo-González JR, Rodríguez-Constenla I Abstract INTRODUCTION: Sativex® is a drug approved for use in the treatment of spasticity in multiple sclerosis. We sought to study the tolerability and effectiveness of this drug

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ÚLTIMOS DESCUBRIMIENTOS SOBRE LOS EFECTOS DE LOS CANNABINOIDES EN TUMORES CEREBRALES

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ÚLTIMOS DESCUBRIMIENTOS: GLIOMA Y GLIOBLASTOMA El Glioma, es un tipo de neoplasia (masa anormal de tejido celular), que se origina en el cerebro o en la médula espinal, aunque es más frecuente que se ubique en el cerebro, en zonas donde hay mayor tejido cerebral (lóbulo frontal, corteza cerebral, tálamo). Surge a partir de las

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Clinical/Therapeutic Approaches for Cannabinoid Ligands in Central and Peripheral Nervous System Diseases: Mini Review.

Related Articles Clinical/Therapeutic Approaches for Cannabinoid Ligands in Central and Peripheral Nervous System Diseases: Mini Review. Clin Neuropharmacol. 2016 Jan 25; Authors: Fijał K, Filip M Abstract OBJECTIVE: Cannabinoids, the components of Cannabis sativa Linnaeus, interact with CB1 and CB2 receptors, which are located both in the central nervous system and in the periphery and

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CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience.

Related Articles CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience. Seizure. 2016 Jan 6;35:41-44 Authors: Tzadok M, Uliel-Siboni S, Linder I, Kramer U, Epstein O, Menascu S, Nissenkorn A, Yosef OB, Hyman E, Granot D, Dor M, Lerman-Sagie T, Ben-Zeev B Abstract PURPOSE: To describe the experience of five Israeli pediatric epilepsy

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The Pharmacological Basis of Cannabis Therapy for Epilepsy.

Related Articles The Pharmacological Basis of Cannabis Therapy for Epilepsy. J Pharmacol Exp Ther. 2016 Jan 19; Authors: Reddy DS, Golub V Abstract Recently, cannabis has been suggested as a potential alternative therapy for refractory epilepsy, which affects 30% of epilepsy patients including children who do not respond to current medications. There is a large

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Cannabidiol for epilepsy: trying to see through the haze.

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Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation.

Related Articles Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. Mol Med. 2016 Jan 8; Authors: Lee WS, Erdelyi K, Matyas C, Mukhopadhyay P, Varga ZV, Liaudet L, Haskó G, Čiháková D, Mechoulam R, Pacher P Abstract RATIONALE: Myocarditis is a major cause of heart failure and sudden cardiac death

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Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases (fibromyalgia syndrome, back pain, osteoarthritis, rheumatoid arthritis) : A systematic review of randomized controlled trials.

Related Articles Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases (fibromyalgia syndrome, back pain, osteoarthritis, rheumatoid arthritis) : A systematic review of randomized controlled trials. Schmerz. 2016 Jan 14; Authors: Fitzcharles MA, Baerwald C, Ablin J, Häuser W Abstract BACKGROUND: In the absence of an ideal treatment for chronic pain

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Medical use of cannabis products : Lessons to be learned from Israel and Canada.

Related Articles Medical use of cannabis products : Lessons to be learned from Israel and Canada. Schmerz. 2016 Jan 14; Authors: Ablin J, Ste-Marie PA, Schäfer M, Häuser W, Fitzcharles MA Abstract INTRODUCTION: The German government intends to reduce the barriers for the medical use of cannabis products. A discussion on the indications and contraindications

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Purified Cannabidiol, the main non-psychotropic component of Cannabis sativa, alone, counteracts neuronal apoptosis in experimental multiple sclerosis.

Related Articles Purified Cannabidiol, the main non-psychotropic component of Cannabis sativa, alone, counteracts neuronal apoptosis in experimental multiple sclerosis. Eur Rev Med Pharmacol Sci. 2015 Dec;19(24):4906-4919 Authors: Giacoppo S, Soundara Rajan T, Galuppo M, Pollastro F, Grassi G, Bramanti P, Mazzon E Abstract OBJECTIVE: Multiple Sclerosis (MS) is a global concern disease leading to a

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Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure.

Related Articles Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure. J Mol Neurosci. 2016 Jan 6; Authors: Hosseinzadeh M, Nikseresht S, Khodagholi F, Naderi N, Maghsoudi N Abstract Abnormal and sometimes severe behavioral and molecular symptoms are usually observed in epileptic

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Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial.

Related Articles Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol. 2015 Dec 23; Authors: Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, Miller I, Flamini R, Wilfong A, Filloux F, Wong M, Tilton N, Bruno P, Bluvstein J, Hedlund J, Kamens R, Maclean J, Nangia S, Singhal

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Sistema endocannabinoide: cómo funciona

¿QUÉ ES EL SISTEMA ENDOCANNABINOIDE? Como Sistema  Endocannabiniode (SEC), se denomina a la relación existente en el cuerpo humano entre los compuestos de la cannabis y el sistema nervioso. No hay ningún otro compuesto en la tierra que coincida con nuestra