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Efficacy of CBD-enriched medical cannabis for treatment of refractory epilepsy in children and adolescents – An observational, longitudinal study.

Related Articles Efficacy of CBD-enriched medical cannabis for treatment of refractory epilepsy in children and adolescents – An observational, longitudinal study. Brain Dev. 2018 Apr 16;: Authors: Hausman-Kedem M, Menascu S, Kramer U Abstract The objective of this observational study was to evaluate the efficacy of medical cannabis for the treatment of refractory epilepsy. Fifty-seven

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The relationship between cannabis use and cortisol levels in youth at ultra high-risk for psychosis.

Related Articles The relationship between cannabis use and cortisol levels in youth at ultra high-risk for psychosis. Psychoneuroendocrinology. 2017 Sep;83:58-64 Authors: Carol EE, Spencer RL, Mittal VA Abstract Recent studies have posited a relationship between cannabis use and the biological stress system, but this critical relationship has not been evaluated during the ultra high-risk (UHR)

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Cannabis and Anti-Cancer Drugs: Societal Usage and Expected Pharmacological Interactions – A Review.

Related Articles Cannabis and Anti-Cancer Drugs: Societal Usage and Expected Pharmacological Interactions – A Review. Fundam Clin Pharmacol. 2018 Apr 16;: Authors: Bouquié R, Deslandes G, Mazaré H, Cogné M, Mahé J, Grégoire M, Jolliet P Abstract Cannabis is a plant that has been used for centuries to relieve a wide range of symptoms. Since

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Sativex® effects on promoter methylation and on CNR1/CNR2 expression in peripheral blood mononuclear cells of progressive multiple sclerosis patients.

Related Articles Sativex® effects on promoter methylation and on CNR1/CNR2 expression in peripheral blood mononuclear cells of progressive multiple sclerosis patients. J Neurol Sci. 2017 Aug 15;379:298-303 Authors: Santoro M, Mirabella M, De Fino C, Bianco A, Lucchini M, Losavio F, Sabino A, Nociti V Abstract Multiple sclerosis (MS) is a chronic demyelinating central nervous

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[Cannabinoid therapy in practice].

Related Articles [Cannabinoid therapy in practice]. Urologe A. 2018 Apr 12;: Authors: Rasche T, Emmert D, Stieber C, Mücke M, Conrad R Abstract BACKGROUND: In recent years, the media and scientists have shown increased interest in cannabis-based drugs. OBJECTIVES: Background information about cannabis-based drugs and their mechanism of action as well as discussion of possible

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Drug Memories: CBD and Addiction

Marijuana smokers have been stereotypically mocked for short-term memory loss, and there is genuine concern about memory impairment due to cannabis consumption, particularly among seniors who are considering cannabis as a therapeutic option. But the importance of forgetting in mental health should not be underestimated. Powered by WPeMatico

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Reefer to the Rescue: The Dope on Cannabidiol as a Multi-Symptom Panacea for Dravet Syndrome.

Reefer to the Rescue: The Dope on Cannabidiol as a Multi-Symptom Panacea for Dravet Syndrome. Epilepsy Curr. 2018 Mar-Apr;18(2):118-120 Authors: Gupta A, Santhakumar V PMID: 29643753 [PubMed] Powered by WPeMatico

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CBD and the Psychedelic Receptor

In a shorthand that drives scientists mad, serotonin is often called ‘the neurotransmitter of happiness.’ This tag is especially troublesome as more and more flaws become apparent in the ‘serotonin hypothesis’ of depression – the idea that depression is caused by a serotonin deficit, which a pill (a serotonin reuptake inhibitor) could correct.1  Serotonin is

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Cannabidiol to Improve Mobility in People with Multiple Sclerosis.

Related Articles Cannabidiol to Improve Mobility in People with Multiple Sclerosis. Front Neurol. 2018;9:183 Authors: Rudroff T, Sosnoff J PMID: 29623067 [PubMed] Powered by WPeMatico

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Cannabis and Humulus: A Family Reunion

Once upon a time, cannabis and humulus (hops) were the same plant. About 27 million years ago, cannabis and hops diverged from their common ancestor and evolved as separate botanical species. Today, cannabis and humulus are identified as distinct species within the same plant family Cannabaceae. One can see a family resemblance in the jagged-edged leaves emblematic

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Treatment Strategies for Dravet Syndrome.

Related Articles Treatment Strategies for Dravet Syndrome. CNS Drugs. 2018 Mar 28;: Authors: Knupp KG, Wirrell EC Abstract Dravet syndrome (DS) is a medically refractory epilepsy that onsets in the first year of life with prolonged seizures, often triggered by fever. Over time, patients develop other seizure types (myoclonic, atypical absences, drops), intellectual disability, crouch

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Antiepileptogenic Effect of Subchronic Palmitoylethanolamide Treatment in a Mouse Model of Acute Epilepsy.

Related Articles Antiepileptogenic Effect of Subchronic Palmitoylethanolamide Treatment in a Mouse Model of Acute Epilepsy. Front Mol Neurosci. 2018;11:67 Authors: Post JM, Loch S, Lerner R, Remmers F, Lomazzo E, Lutz B, Bindila L Abstract Research on the antiepileptic effects of (endo-)cannabinoids has remarkably progressed in the years following the discovery of fundamental role of

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Better Than Cannabis?

In recent years, cannabis has been at the center of one of the most important developments in modern science, which has significantly advanced our understanding of health and disease. Powered by WPeMatico

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Amyotrophic Lateral Sclerosis (ALS) and Cannabinoids

Charlie Wedemeyer was one of Hawaii’s greatest athletes when he attended Punahou School in the 1960’s. He was the quarterback for the football team, but also excelled at basketball and baseball. Charlie was named the Hawaii Prep Athlete of the 1960’s and went on to play football for Michigan State. Powered by WPeMatico

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Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay.

Related Articles Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay. Transplant Proc. 2018 Mar;50(2):461-464 Authors: Cuñetti L, Manzo L, Peyraube R, Arnaiz J, Curi L, Orihuela S Abstract BACKGROUND: Chronic pain is a major therapeutic problem in kidney transplant patients owing to nephrotoxicity associated with nonsteroidal antiiflammatory drugs. Benefits in chronic pain

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Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model.

Related Articles Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model. Br J Pharmacol. 2018 Mar 25;: Authors: Khan AA, Shekh-Ahmad T, Khalil A, Walker MC, Ali AB Abstract BACKGROUND AND PURPOSE: A non-psychoactive phytocannabinoid, cannabidiol (CBD), shows promising results as an effective potential antiepileptic drug in some forms

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Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.

Related Articles Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome. Neurology. 2018 Mar 14;: Authors: Devinsky O, Patel AD, Thiele EA, Wong MH, Appleton R, Harden CL, Greenwood S, Morrison G, Sommerville K, GWPCARE1 Part A Study Group Abstract OBJECTIVE: To evaluate the safety and preliminary pharmacokinetics of a pharmaceutical formulation of purified cannabidiol

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Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia.

Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia. Epilepsy Behav. 2018 Mar 08;: Authors: Neubauer D, Perković Benedik M, Osredkar D Abstract PURPOSE: Refractory epilepsies in children present a major burden for patients and their families. Cannabidiol (CBD) has been suggested as a potential treatment for refractory

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Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence.

Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence. J Neurol Neurosurg Psychiatry. 2018 Mar 06;: Authors: Stockings E, Zagic D, Campbell G, Weier M, Hall WD, Nielsen S, Herkes GK, Farrell M, Degenhardt L Abstract Review evidence for cannabinoids as adjunctive treatments for treatment-resistant epilepsy. Systematic search of

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Cannabis-based medicines for chronic neuropathic pain in adults.

Cannabis-based medicines for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2018 Mar 07;3:CD012182 Authors: Mücke M, Phillips T, Radbruch L, Petzke F, Häuser W Abstract BACKGROUND: This review is one of a series on drugs used to treat chronic neuropathic pain. Estimates of the population prevalence of chronic pain with neuropathic components range

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Blunted stress reactivity in chronic cannabis users.

Related Articles Blunted stress reactivity in chronic cannabis users. Psychopharmacology (Berl). 2017 Aug;234(15):2299-2309 Authors: Cuttler C, Spradlin A, Nusbaum AT, Whitney P, Hinson JM, McLaughlin RJ Abstract RATIONALE: One of the most commonly cited reasons for chronic cannabis use is to cope with stress. Consistent with this, cannabis users have shown reduced emotional arousal and

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Managing Nausea with Cannabis

A patient’s perspective Laura was a physician who spent much of her clinical time treating substance abuse disorders, and she had no recent experience with cannabis herself. Her aversion to using cannabis when she was going through chemotherapy for breast cancer did not surprise me. Nausea, and the anxiety that preceded its inevitable occurrence, were disabling.

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The current state and future perspectives of cannabinoids in cancer biology.

Related Articles The current state and future perspectives of cannabinoids in cancer biology. Cancer Med. 2018 Feb 23;: Authors: Śledziński P, Zeyland J, Słomski R, Nowak A Abstract To date, cannabinoids have been allowed in the palliative medicine due to their analgesic and antiemetic effects, but increasing number of preclinical studies indicates their anticancer properties.

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Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin.

Related Articles Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin. Front Mol Neurosci. 2018;11:32 Authors: Maggio N, Shavit Stein E, Segal M Abstract Epilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became apparent that cannabinoids help patients to cope

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Species-specific susceptibility to cannabis-induced convulsions.

Related Articles Species-specific susceptibility to cannabis-induced convulsions. Br J Pharmacol. 2018 Feb 19;: Authors: Whalley BJ, Lin H, Bell L, Hill T, Patel A, Gray RA, Elizabeth Roberts C, Devinsky O, Bazelot M, Williams CM, Stephens GJ Abstract BACKGROUND AND PURPOSE: Numerous claims are made for cannabis’ therapeutic utility upon human seizures, but concerns persist

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The Cannabinoids Δ8THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation.

Related Articles The Cannabinoids Δ8THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation. Cannabis Cannabinoid Res. 2018;3(1):11-20 Authors: Thapa D, Cairns EA, Szczesniak AM, Toguri JT, Caldwell MD, Kelly MEM Abstract Background and Purpose: Corneal injury can result in dysfunction of corneal nociceptive signaling and corneal sensitization. Activation of the

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Complementary and Alternative Medicine.

Related Articles Complementary and Alternative Medicine. Inflamm Bowel Dis. 2016 Jun;22(6):1523-30 Authors: Quezada SM, Briscoe J, Cross RK Abstract Inflammatory bowel disease is a complex, chronic, multifactorial inflammatory disorder of the digestive tract. Standard therapies include immunosuppressive and biological treatments, but there is increasing interest in the potential benefit of complementary and alternative medicine for

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Cannabinoid-induced cell death in endometrial cancer cells: involvement of TRPV1 receptors in apoptosis.

Related Articles Cannabinoid-induced cell death in endometrial cancer cells: involvement of TRPV1 receptors in apoptosis. J Physiol Biochem. 2018 Feb 13;: Authors: Fonseca BM, Correia-da-Silva G, Teixeira NA Abstract Among a variety of phytocannabinoids, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most promising therapeutic compounds. Besides the well-known palliative effects in cancer patients, cannabinoids have

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Cannabis for paediatric epilepsy: challenges and conundrums.

Cannabis for paediatric epilepsy: challenges and conundrums. Med J Aust. 2018 Feb 19;208(3):132-136 Authors: Chen KA, Farrar MA, Cardamone M, Lawson JA Abstract Research is expanding for the use of cannabidiol as an anticonvulsant drug. The mechanism of cannabidiol in paediatric epilepsy is unclear but is thought to play a role in modulation of synaptic

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Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center.

Related Articles Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center. Epilepsy Behav. 2018 Feb 08;: Authors: Porcari GS, Fu C, Doll ED, Carter EG, Carson RP Abstract Medically refractory epilepsy continues to be a challenge worldwide, and despite an increasing number of medical therapies, approximately

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Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or cannabigerol.

Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or cannabigerol. Fitoterapia. 2018 Feb 07;: Authors: Smeriglio A, Giofrè SV, Galati EM, Monforte MT, Cicero N, D’Angelo V, Grassi G, Circosta C Abstract Aldose reductase (ALR2) is a key enzyme involved in diabetic complications and the search for new

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Growing Pains: Can Sustainable Farmers Survive Legalization?

The California counties of Humboldt, Mendocino and Trinity, which comprise the Emerald Triangle, emerged as the epicenter of domestic cannabis cultivation in the late 1970s and early ‘80s. After the Golden State legalized medical marijuana in 1996, the nascent cannabis industry spread throughout much of Northern California’s remote regions and into the Central Valley. But

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The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users.

The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users. Cannabis Cannabinoid Res. 2018;3(1):1-10 Authors: Batalla A, Lorenzetti V, Chye Y, Yücel M, Soriano-Mas C, Bhattacharyya S, Torrens M, Crippa JAS, Martín-Santos R Abstract Introduction: Hippocampal neuroanatomy is affected by genetic variations in dopaminergic

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Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study.

Related Articles Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study. Psychopharmacology (Berl). 2017 Jul;234(13):1933-1943 Authors: Androvicova R, Horacek J, Tintera J, Hlinka J, Rydlo J, Jezova D, Balikova M, Hlozek T, Miksatkova P, Kuchar M, Roman M, Tomicek P, Tyls F, Viktorinova M, Palenicek

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The therapeutic use of cannabinoids: Forensic aspects.

Related Articles The therapeutic use of cannabinoids: Forensic aspects. Forensic Sci Int. 2016 Aug;265:200-3 Authors: Indorato F, Liberto A, Ledda C, Romano G, Barbera N Abstract UNLABELLED: Since 2013 in the Italian market has been introduced the Nabiximols, a drug containing two of the main active cannabinoids: Δ(9)-tetrahydrocannabinol (Δ(9)-THC) and cannabidiol (CBD). This drug has

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Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial.

Related Articles Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2018 Jan 25;: Authors: Thiele EA, Marsh ED, French JA, Mazurkiewicz-Beldzinska M, Benbadis SR, Joshi C, Lyons PD, Taylor A, Roberts C, Sommerville K, GWPCARE4 Study Group Abstract BACKGROUND: Patients with Lennox-Gastaut syndrome, a rare,

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Use of N-Acetylcysteine in Psychiatric Conditions among Children and Adolescents: A Scoping Review.

Use of N-Acetylcysteine in Psychiatric Conditions among Children and Adolescents: A Scoping Review. Cureus. 2017 Nov 29;9(11):e1888 Authors: Naveed S, Amray A, Waqas A, Chaudhary AM, Azeem MW Abstract N-acetylcysteine (NAC) is a well-known antidote for acetaminophen toxicity and is easily available over the counter. It has antioxidant and anti-inflammatory properties and an established tolerance

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An interaction between warfarin and cannabidiol, a case report.

Related Articles An interaction between warfarin and cannabidiol, a case report. Epilepsy Behav Case Rep. 2018;9:10-11 Authors: Grayson L, Vines B, Nichol K, Szaflarski JP, UAB CBD Program Abstract •An interaction between warfarin and cannabidiol is described•The mechanisms of cannabidiol and warfarin metabolism are reviewed•Mechanism of the interaction is proposed•INR should be monitored in patients

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Thank you Dennis Peron

To accommodate a deluge of new members, Dennis Peron moved the San Francisco Cannabis Buyers Club in 1995 to a converted five-story warehouse at 1444 Market Street, a busy locale near the San Francisco Civic Center. Powered by WPeMatico

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Green Rush Blues: California Cannabis After Legalization

The huge underground cannabis economy was woven into the commercial fabric of California long before the 2016 passage of Proposition 64, which legalized marijuana for adult use. Transforming a shadowy, multibillion-dollar industry into a heavily taxed and regulated structure presents unique and enormous challenges. Who will gain and who will lose under the new regime?

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Prospects of Cannabidiol for Easing Status Epilepticus-Induced Epileptogenesis and Related Comorbidities.

Related Articles Prospects of Cannabidiol for Easing Status Epilepticus-Induced Epileptogenesis and Related Comorbidities. Mol Neurobiol. 2018 Jan 25;: Authors: Upadhya D, Castro OW, Upadhya R, Shetty AK Abstract The hippocampus is one of the most susceptible regions in the brain to be distraught with status epilepticus (SE) induced injury. SE can occur from numerous causes

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Cannabinoid-Pharmaceutical Interactions: What You Need to Know

Interactions between medications are very common, especially in elderly populations that medicate for pain, diabetes and high cholesterol. The geriatric population is also the fastest-growing group of medical cannabis users. Cannabis has demonstrated efficacy in treating pain, and some phytocannabinoids have been suggested for various metabolic conditions. Powered by WPeMatico

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Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?

Related Articles Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last? J Epilepsy Res. 2017 Dec;7(2):61-76 Authors: Perucca E Abstract The interest in cannabis-based products for the treatment of refractory epilepsy has skyrocketed in recent years. Marijuana and other cannabis products with high content in Δ(9) – tetrahydrocannabinol (THC), utilized primarily for recreational purposes,

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Strokes are possible complications of cannabinoids use.

Related Articles Strokes are possible complications of cannabinoids use. Epilepsy Behav. 2017 May;70(Pt B):355-363 Authors: Wolff V, Jouanjus E Abstract It is critically important to identify all factors that may play a role in the recent increase of the incidence of stroke among the young population. Considering the worldwide use of cannabinoids (cannabis and synthetic

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Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease.

Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease. Liver Int. 2018 Jan 17;: Authors: Adejumo AC, Ajayi TO, Adegbala OM, Adejumo KL, Alliu S, Akinjero AM, Onyeakusi NE, Ojelabi O, Bukong TN Abstract BACKGROUND: Abusive alcohol use has well-established health risks including causing liver disease (ALD) characterized by alcoholic

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Conservative treatment of patients with thromboangiitis obliterans or cannabis-associated arteritis presenting with critical lower limb ischaemia.

Related Articles Conservative treatment of patients with thromboangiitis obliterans or cannabis-associated arteritis presenting with critical lower limb ischaemia. Vasa. 2017 Oct;46(6):471-475 Authors: Galyfos G, Kerasidis S, Kastrisios G, Giannakakis S, Sachmpazidis I, Anastasiadou C, Geropapas G, Papapetrou A, Papacharalampous G, Maltezos C Abstract BACKGROUND: Proper management of patients with thromboangiitis obliterans (TAO) or cannabis-associated arteritis

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Practical considerations in medical cannabis administration and dosing.

Related Articles Practical considerations in medical cannabis administration and dosing. Eur J Intern Med. 2018 Jan 04;: Authors: MacCallum CA, Russo EB Abstract Cannabis has been employed medicinally throughout history, but its recent legal prohibition, biochemical complexity and variability, quality control issues, previous dearth of appropriately powered randomised controlled trials, and lack of pertinent education

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Cannabis and Pediatric Inflammatory Bowel Disease: Change Blossoms a Mile High.

Related Articles Cannabis and Pediatric Inflammatory Bowel Disease: Change Blossoms a Mile High. J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):265-271 Authors: Hoffenberg EJ, Newman H, Collins C, Tarbell S, Leinwand K Abstract The trend toward decriminalization of cannabis (marijuana) continues sweeping across the United States. Colorado has been a leader of legalization of medical and recreational

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Anti-inflammatory activity of cannabinoid receptor 2 ligands in primary hPDL fibroblasts.

Related Articles Anti-inflammatory activity of cannabinoid receptor 2 ligands in primary hPDL fibroblasts. Arch Oral Biol. 2017 Dec 06;87:79-85 Authors: Abidi AH, Presley CS, Dabbous M, Tipton DA, Mustafa SM, Moore BM Abstract OBJECTIVES: Approximately 65 million adults in the US have periodontitis, causing tooth loss and decreased quality of life. Cannabinoids modulate immune responses,

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Sex and age specific effects of delta-9-tetrahydrocannabinol during the periadolescent period in the rat: The unique susceptibility of the prepubescent animal.

Related Articles Sex and age specific effects of delta-9-tetrahydrocannabinol during the periadolescent period in the rat: The unique susceptibility of the prepubescent animal. Neurotoxicol Teratol. 2016 Nov – Dec;58:88-100 Authors: Silva L, Black R, Michaelides M, Hurd YL, Dow-Edwards D Abstract Adolescents who use marijuana are more likely to exhibit anxiety, depression, and other mood

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Cannabidiol restores intestinal barrier dysfunction and inhibits the apoptotic process induced by Clostridium difficile toxin A in Caco-2 cells.

Related Articles Cannabidiol restores intestinal barrier dysfunction and inhibits the apoptotic process induced by Clostridium difficile toxin A in Caco-2 cells. United European Gastroenterol J. 2017 Dec;5(8):1108-1115 Authors: Gigli S, Seguella L, Pesce M, Bruzzese E, D’Alessandro A, Cuomo R, Steardo L, Sarnelli G, Esposito G Abstract Background: Clostridium difficile toxin A is responsible for

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Treasure Hunt

Nine ways that scientists are targeting the endocannabinoid system with synthetic drugs and isolates By Martin A. Lee On December 13, 2017 In recent years, cannabis has been at the center of one of the most important developments in modern science, which has significantly advanced our understanding of health and disease. Research on marijuana’s effects led

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Anticonvulsant Effects of Cannabidiol in Dravet Syndrome.

Related Articles Anticonvulsant Effects of Cannabidiol in Dravet Syndrome. Epilepsy Curr. 2017 Sep-Oct;17(5):281-282 Authors: Koubeissi M PMID: 29225539 [PubMed] Powered by WPeMatico

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Hypothalamic-pituitary-adrenal axis measures and cognitive abilities in early psychosis: Are there sex differences?

Related Articles Hypothalamic-pituitary-adrenal axis measures and cognitive abilities in early psychosis: Are there sex differences? Psychoneuroendocrinology. 2016 Oct;72:54-62 Authors: Labad J, Gutiérrez-Zotes A, Creus M, Montalvo I, Cabezas Á, Solé M, Ortega L, Algora MJ, Sánchez-Gistau V, Vilella E Abstract INTRODUCTION: Measures of hypothalamic-pituitary-adrenal (HPA) axis activity such as increased diurnal cortisol levels or a

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Cannabinoids for epilepsy: What do we know and where do we go?

Cannabinoids for epilepsy: What do we know and where do we go? Epilepsia. 2017 Dec 06;: Authors: Brodie MJ, Ben-Menachem E Abstract Over the past decade there has been an increasing interest in using cannabinoids to treat a range of epilepsy syndromes following reports of some remarkable responses in individual patients. The situation is complicated

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Systematic review: interventions for abdominal pain management in inflammatory bowel disease.

Related Articles Systematic review: interventions for abdominal pain management in inflammatory bowel disease. Aliment Pharmacol Ther. 2017 Jul;46(2):115-125 Authors: Norton C, Czuber-Dochan W, Artom M, Sweeney L, Hart A Abstract BACKGROUND: Abdominal pain is frequently reported by people with inflammatory bowel disease (IBD), including in remission. Pain is an under-treated symptom. AIM: To systematically review

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HIV-infected cannabis users have lower circulating CD16+ monocytes and IP-10 levels compared to non-using HIV patients.

HIV-infected cannabis users have lower circulating CD16+ monocytes and IP-10 levels compared to non-using HIV patients. AIDS. 2017 Nov 30;: Authors: Rizzo MD, Crawford RB, Henriquez JE, Aldhamen Y, Gulick P, Amalfitano A, Kaminski NE Abstract OBJECTIVE: Chronic immune activation and elevated numbers of circulating activated monocytes (CD16) are implicated in HIV-associated neuroinflammation. The objective

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The Origins of Reefer Madness [Book Excerpt]

On August 11, 1930, Harry Jacob Anslinger became the director of the newly formed Federal Bureau of Narcotics (FBN) in Washington, D.C. The Voldemort of vipers, he would run the FBN with an iron fist through six presidential administrations spanning more than three decades. By Martin A. Lee On October 15, 2017 Excerpted from Smoke Signals:

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Simple and fast gas-chromatography mass spectrometry assay to assess delta 9-tetrahydrocannabinol and cannabidiol in dogs treated with medical cannabis for canine epilepsy.

Simple and fast gas-chromatography mass spectrometry assay to assess delta 9-tetrahydrocannabinol and cannabidiol in dogs treated with medical cannabis for canine epilepsy. Curr Pharm Biotechnol. 2017 Nov 21;: Authors: Rotolo MC, Graziano S, Pellegrini M, Corlazzoli D, Antinori L, Porcarelli L, Pichini S Abstract BACKGROUND: To date, an increasing number of pet owners, especially in

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Bugs, Mold and Excrement

Welcome to the Brave New World of California Cannabis By Adrian Devitt-Lee On November 26, 2017 Project CBD critiques the new regulations for America’s largest marijuana market On November 16, 2017, California officials released a new set of regulations for cannabis manufacturing, testing, and growing. In many respects, these updates are a significant improvement to

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Epilepsy, Endocannabinoids and Phytocannabinoids

Cannabidiol and several other cannabis components can help patients with seizure disorders, and sometimes it’s best to combine CBD with conventional anti-epileptic meds. By Stacey Kerr, M.D. On November 25, 2017 Highlights:  • More than 5 million Americans suffer from epilepsy. • CBD is helping many patients, including children with seizure disorders. • THCA, the

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Pharmacological Foundations of Cannabis Chemovars.

Pharmacological Foundations of Cannabis Chemovars. Planta Med. 2017 Nov 21;: Authors: Lewis MA, Russo EB, Smith KM Abstract An advanced Mendelian Cannabis breeding program has been developed utilizing chemical markers to maximize the yield of phytocannabinoids and terpenoids with the aim to improve therapeutic efficacy and safety. Cannabis is often divided into several categories based

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Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings.

Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings. Eur J Pain. 2017 Nov 21;: Authors: Lötsch J, Weyer-Menkhoff I, Tegeder I Abstract Cannabinoids have a long record of recreational and medical use and become increasingly approved for pain therapy. This development is based on preclinical and human experimental research summarized in

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Availability and approval of cannabis-based medicines for chronic pain management and palliative/supportive care in Europe: A survey of the status in the chapters of the European Pain Federation.

Related Articles Availability and approval of cannabis-based medicines for chronic pain management and palliative/supportive care in Europe: A survey of the status in the chapters of the European Pain Federation. Eur J Pain. 2017 Nov 13;: Authors: Krcevski-Skvarc N, Wells C, Häuser W Abstract BACKGROUND: There is considerable public and political interest in the use

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More FDA Warnings, Mislabeled CBD Products & Police Raids

A series of police raids in North Dakota has set the stage for a courtroom showdown regarding the legal status of cannabidiol (CBD), the non-intoxicating cannabis component with significant medical properties. Thus far, it’s not going well for purveyors of the claim that hemp-derived CBD is legal in all 50 U.S. states. By Martin A.

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CBD as Preventative Medicine

An excerpt from CBD: A Patient’s Guide to Medicinal Cannabis by Leonard Leinow & Juliana Birnbaum By By Leonard Leinow & Juliana Birnbaum On November 07, 2017 A new book discusses seven ways CBD-rich cannabis can be used to prevent disease Highlights:  CBD has anti-inflammatory properties and studies suggest that it can reduce the risk

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[Cannabis and lung. What we know and everything we don’t know yet].

[Cannabis and lung. What we know and everything we don’t know yet]. Rev Pneumol Clin. 2017 Nov 07;: Authors: Urban T, Hureaux J Abstract Cannabis use increased sharply from 2010 to 2014 in France. Cannabis is often consumed with tobacco, although the use of marijuana is developing. Tobacco and cannabis smoke have many common characteristics

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Cannabidiol as a treatment for epilepsy.

Cannabidiol as a treatment for epilepsy. J Neurol. 2017 Nov 09;: Authors: Pickrell WO, Robertson NP PMID: 29124331 [PubMed – as supplied by publisher] Powered by WPeMatico

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Single-Dose Pharmacokinetics of Oral Cannabidiol Following Administration of PTL101: A New Formulation Based on Gelatin Matrix Pellets Technology.

Single-Dose Pharmacokinetics of Oral Cannabidiol Following Administration of PTL101: A New Formulation Based on Gelatin Matrix Pellets Technology. Clin Pharmacol Drug Dev. 2017 Nov 10;: Authors: Atsmon J, Heffetz D, Deutsch L, Deutsch F, Sacks H Abstract Cannabidiol (CBD) is the main nonpsychoactive component of the cannabis plant. It has been associated with antiseizure, antioxidant,

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Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation.

Related Articles Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation. Sci Rep. 2017 Nov 06;7(1):14542 Authors: Zgair A, Lee JB, Wong JCM, Taha DA, Aram J, Di Virgilio D, McArthur JW, Cheng YK, Hennig IM, Barrett DA, Fischer PM, Constantinescu CS, Gershkovich P

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Efficacy and safety of cannabis for treating children with refractory epilepsy.

Related Articles Efficacy and safety of cannabis for treating children with refractory epilepsy. Nurs Child Young People. 2017 Sep 11;29(7):32-37 Authors: Neale M Abstract The aim of this literature review was to examine the evidence base for the safety and efficacy of cannabis in treating children with refractory epilepsy. Clinical and medical databases were searched

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From Clone to Concentrate: How CBD Cannabis Oil is Made

See how CBD cannabis oil is extracted and produced. By Project CBD On November 08, 2017 See how cannabis oil is extracted and produced. Copyright, Project CBD. May not be reprinted without permission. Powered by WPeMatico

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Developmental effects of cannabidiol and Δ9-tetrahydrocannabinol in zebrafish.

Developmental effects of cannabidiol and Δ9-tetrahydrocannabinol in zebrafish. Toxicol Sci. 2017 Nov 02;: Authors: Carty DR, Thornton C, Gledhill J, Willett KL Abstract Cannabidiol (CBD) has gained much attention in the past several years for its therapeutic potential in the treatment of drug-resistant epilepsy, such as Dravet Syndrome. While CBD has shown anecdotal efficacy in

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Cannabis sativa (Hemp) Seeds, Δ(9)-Tetrahydrocannabinol, and Potential Overdose.

Related Articles Cannabis sativa (Hemp) Seeds, Δ(9)-Tetrahydrocannabinol, and Potential Overdose. Cannabis Cannabinoid Res. 2017;2(1):274-281 Authors: Yang Y, Lewis MM, Bello AM, Wasilewski E, Clarke HA, Kotra LP Abstract Introduction:Cannabis sativa (hemp) seeds are popular for their high nutrient content, and strict regulations are in place to limit the amount of potentially harmful phytocannabinoids, especially Δ(9)-tetrahydrocannabinol

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Anti-Inflammatory Activity in Colon Models Is Derived from Δ9-Tetrahydrocannabinolic Acid That Interacts with Additional Compounds in Cannabis Extracts.

Anti-Inflammatory Activity in Colon Models Is Derived from Δ9-Tetrahydrocannabinolic Acid That Interacts with Additional Compounds in Cannabis Extracts. Cannabis Cannabinoid Res. 2017;2(1):167-182 Authors: Nallathambi R, Mazuz M, Ion A, Selvaraj G, Weininger S, Fridlender M, Nasser A, Sagee O, Kumari P, Nemichenizer D, Mendelovitz M, Firstein N, Hanin O, Konikoff F, Kapulnik Y, Naftali T,

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Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain.

Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain. Cannabis Cannabinoid Res. 2017;2(1):210-216 Authors: Ryz NR, Remillard DJ, Russo EB Abstract Introduction: The roots of the cannabis plant have a long history of medical use stretching back millennia. However, the therapeutic potential of cannabis roots has been largely ignored in modern

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Cannabis & Sleep Disturbances

Quality sleep is critical to human emotional, mental and physical health, yet it eludes between 50-70 million Americans. In this report, we will explore why sleep matters, the role of the endocannabinoid system in sleep, and how cannabis and its components—in particular, CBD and THC—may benefit those with sleep issues. By Nishi Whitely On October

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The use of cannabidiol for seizure management in patients with brain tumor-related epilepsy.

Related Articles The use of cannabidiol for seizure management in patients with brain tumor-related epilepsy. Neurocase. 2017 Oct 24;:1-5 Authors: Warren PP, Bebin EM, Nabors LB, Szaflarski JP Abstract Epilepsy, commonly encountered by patients with brain tumors, is often refractory to standard therapies. Our aim was to examine the safety and efficacy of pharmaceutical grade

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A case for cannabidiol in Wolf-Hirschhorn syndrome seizure management.

Related Articles A case for cannabidiol in Wolf-Hirschhorn syndrome seizure management. Am J Med Genet A. 2017 Feb;173(2):324-326 Authors: Ho KS, Wassman ER Abstract Complex, and sometimes intractable, seizures affect the quality of life and cognitive development of over 90% of individuals with Wolf-Hirschhorn syndrome (WHS). Fine resolution genotype-phenotype mapping of the WHS locus recently

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Red Cross Meets Green Cross

A major legal medical marijuana factory in Northern California has become the headquarters of the American Red Cross’ relief efforts for tens of thousands of displaced evacuees fleeing the state’s historic series of wildfires. By David Downs On October 17, 2017 From Greenstate.com A major legal medical marijuana factory in Northern California has become the headquarters

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Fire, Brimstone & Dioxin

Heavy smoke has blanketed the skies in the nine-county San Francisco Bay Area, poisoning the air to an unprecedented degree and prompting air quality alerts and health advisories throughout the region. By Adrian Devitt-Lee On October 16, 2017 Toxic Smoke Threatens Cannabis Crop and Public Health Highlights:  Smoke from major fires will contaminate crops in

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Cannabinoids in Pain Management and Palliative Medicine.

Cannabinoids in Pain Management and Palliative Medicine. Dtsch Arztebl Int. 2017 Sep 22;114(38):627-634 Authors: Häuser W, Fitzcharles MA, Radbruch L, Petzke F Abstract BACKGROUND: There are conflicting interpretations of the evidence regarding the efficacy, tolerability, and safety of cannabinoids in pain management and palliative medicine. METHODS: We conducted a systematic review (SR) of systematic reviews

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Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.

Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A. 2017 Oct 02;: Authors: Kaplan JS, Stella N, Catterall WA, Westenbroek RE Abstract Worldwide medicinal use of cannabis is rapidly escalating, despite limited evidence of its efficacy from preclinical and clinical studies. Here we show

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Is cannabis an effective treatment for joint pain?

Is cannabis an effective treatment for joint pain? Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):59-67 Authors: Miller RJ, Miller RE Abstract Cannabis has been used to treat pain for thousands of years. However, since the early part of the 20th century, laws restricting cannabis use have limited its evaluation using modern scientific criteria. Over the

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Evaluating Sativex® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis.

Related Articles Evaluating Sativex® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis. Pain Med. 2016 Jun;17(6):1145-54 Authors: Russo M, Naro A, Leo A, Sessa E, D’Aleo G, Bramanti P, Calabrò RS Abstract OBJECTIVE: The aim of our study was to better investigate the role of Sativex(®) in improving pain in multiple

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Cannabidiol and Palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon.

Related Articles Cannabidiol and Palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon. Clin Sci (Lond). 2017 Sep 27;: Authors: Couch DG, Tasker C, Theophilidou E, Lund JN, O’Sullivan SE Abstract Objective: We sought to quantify the anti-inflammatory effects of two cannabinoid drugs: cannabidiol (CBD) and palmitoylethanolamide (PEA), in cultured cell lines and compared this

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A Resurging Boom in New Drugs for Epilepsy and Brain Disorders.

Related Articles A Resurging Boom in New Drugs for Epilepsy and Brain Disorders. Expert Rev Clin Pharmacol. 2017 Sep 28;: Authors: Younus I, Reddy DS Abstract INTRODUCTION: Epilepsy is one of the most common neurological diseases affecting approximately 50 million people worldwide. Despite many advances in epilepsy research, nearly a third of patients with epilepsy

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Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception.

Related Articles Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception. Behav Brain Res. 2017 Sep 18;: Authors: Ellis LD, Berrue F, Morash M, Achenbach JC, Hill J, McDougall JJ Abstract It has been established that both adult and larval zebrafish are capable of showing nociceptive responses to

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Medical marijuana for the treatment of vismodegib-related muscle spasm.

Related Articles Medical marijuana for the treatment of vismodegib-related muscle spasm. JAAD Case Rep. 2017 Sep;3(5):438-440 Authors: Yuan JT, Tello TL, Hultman C, Barker CA, Arron ST, Yom SS PMID: 28932790 [PubMed] Powered by WPeMatico

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[Stress and psychotic transition: A literature review].

Related Articles [Stress and psychotic transition: A literature review]. Encephale. 2016 Aug;42(4):367-73 Authors: Chaumette B, Kebir O, Mam Lam Fook C, Bourgin J, Godsil BP, Gaillard R, Jay TM, Krebs MO Abstract BACKGROUND: Psychiatric disorders are consistent with the gene x environment model, and non-specific environmental factors such as childhood trauma, urbanity, and migration have

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[Delta-9-tetrahydrocannabinol-cannabidiol in the treatment of spasticity in chronic spinal cord injury: a clinical experience].

Related Articles [Delta-9-tetrahydrocannabinol-cannabidiol in the treatment of spasticity in chronic spinal cord injury: a clinical experience]. Rev Neurol. 2017 Oct 01;65(7):295-302 Authors: Grao-Castellote C, Torralba-Collados F, Gonzalez LM, Giner-Pascual M Abstract INTRODUCTION: Spasticity in chronic spinal cord injury is a condition that can have negative repercussions on the patient’s quality of life. Its treatment is

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Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents.

Related Articles Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents. Pharmacotherapy. 2016 Jul;36(7):781-96 Authors: Fasinu PS, Phillips S, ElSohly MA, Walker LA Abstract States and the federal government are under growing pressure to legalize the use of cannabis products for medical purposes in the United States. Sixteen states have legalized (or decriminalized

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Beyond Cannabis: Plants and the Endocannabinoid System.

Related Articles Beyond Cannabis: Plants and the Endocannabinoid System. Trends Pharmacol Sci. 2016 Jul;37(7):594-605 Authors: Russo EB Abstract Plants have been the predominant source of medicines throughout the vast majority of human history, and remain so today outside of industrialized societies. One of the most versatile in terms of its phytochemistry is cannabis, whose investigation

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Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as Adjunctive Therapy in Advanced Cancer Patients With Chronic Uncontrolled Pain.

Related Articles Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as Adjunctive Therapy in Advanced Cancer Patients With Chronic Uncontrolled Pain. J Pain Symptom Manage. 2017 Sep 15;: Authors: Lichtman AH, Lux EA, McQuade R, Rossetti S, Sanchez R, Sun W, Wright S, Kornyeyeva E, Fallon MT Abstract CONTEXT: Prior phase 2/3

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Vicki & Aubrie Hill and Intractable Epilepsy

The story of Aubrey Hill and her mom who moved to California to get reliable access to cannabis oil to treat her intractable epilepsy — with positive results. By Stacey Marie Kerr MD, Hawaiian Ethos Medical Director On September 14, 2017 A patient story with a happy ending A few weeks ago I met Vicki

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Statement on Cannabidiol for the FDA

Project CBD responds to the Food and Drug Administration’s call for statements on the use of CBD. By On September 14, 2017 Sept. 13, 2017 The legal and regulatory status of cannabidiol (CBD), a component of the cannabis plant with a huge therapeutic upside, has emerged as a contentious subject in the United States, even though

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[Cannabis use in Epilepsy. Current situation in Argentina and abroad].

Related Articles [Cannabis use in Epilepsy. Current situation in Argentina and abroad]. Vertex. 2016 Nov;XXVII(130):457-462 Authors: Kochen S Abstract Although at present we have over 20 different types of drugs for epilepsy, 30 to 40% of patients continue to have seizures. Preliminary data from human studies suggest that cannabis, cannabidiol in particular, is effective in

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Cannabidiol, a novel inverse agonist for GPR12.

Related Articles Cannabidiol, a novel inverse agonist for GPR12. Biochem Biophys Res Commun. 2017 Sep 06;: Authors: Brown KJ, Laun AS, Song ZH Abstract GPR12 is a constitutively active, Gs protein-coupled receptor that currently has no confirmed endogenous ligands. GPR12 may be involved in physiological processes such as maintenance of oocyte meiotic arrest and brain

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Cannabis constituent synergy in a mouse neuropathic pain model.

Cannabis constituent synergy in a mouse neuropathic pain model. Pain. 2017 Sep 01;: Authors: Casey SL, Atwal N, Vaughan CW Abstract Cannabis and its psychoactive constituent Δ9-tetrahydrocannabinol (THC) have efficacy against neuropathic pain however, this is hampered by their side-effects. It has been suggested that co-administration with another major constituent cannabidiol (CBD) might enhance the

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Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.

Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain. 2017 Sep 01;: Authors: Philpott HT, O’Brien M, McDougall JJ Abstract Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a non-euphoria producing constituent of cannabis that has the

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A randomised controlled cross-over double-blind pilot study protocol on THC:CBD oromucosal spray efficacy as an add-on therapy for post-stroke spasticity.

A randomised controlled cross-over double-blind pilot study protocol on THC:CBD oromucosal spray efficacy as an add-on therapy for post-stroke spasticity. BMJ Open. 2017 Sep 07;7(9):e016843 Authors: Marinelli L, Balestrino M, Mori L, Puce L, Rosa GM, Giorello L, Currà A, Fattapposta F, Serrati C, Gandolfo C, Abbruzzese G, Trompetto C Abstract INTRODUCTION: Stroke is the

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Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia.

Related Articles Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 03;75:94-105 Authors: Mori MA, Meyer E, Soares LM, Milani H, Guimarães FS, de Oliveira RM Abstract This study investigated the effects of cannabidiol (CBD), a non-psychotomimetic phytochemical present in Cannabis sativa, on the cognitive and

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Gut Check: Does CBD change to THC in the stomach?

Project CBD exposes fraud and financial interests behind misleading report suggesting that CBD converts to THC in the stomach. By Project CBD On February 14, 2017 In 2016, a new journal Cannabis and Cannabinoid Research published a paper suggesting that non-psychoactive cannabidiol (CBD) converts to psychoactive tetrahydrocannabinol (THC) in the stomach. The controversial paper was

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A selective review of medical cannabis in cancer pain management.

Related Articles A selective review of medical cannabis in cancer pain management. Ann Palliat Med. 2017 Aug 23;: Authors: Blake A, Wan BA, Malek L, DeAngelis C, Diaz P, Lao N, Chow E, O’Hearn S Abstract Insufficient management of cancer-associated chronic and neuropathic pain adversely affects patient quality of life. Patients who do not respond

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A Conversion of Oral Cannabidiol to Delta9-Tetrahydrocannabinol Seems Not to Occur in Humans.

Related Articles A Conversion of Oral Cannabidiol to Delta9-Tetrahydrocannabinol Seems Not to Occur in Humans. Cannabis Cannabinoid Res. 2017;2(1):81-86 Authors: Nahler G, Grotenhermen F, Zuardi AW, Crippa JAS Abstract Cannabidiol (CBD), a major cannabinoid of hemp, does not bind to CB1 receptors and is therefore devoid of psychotomimetic properties. Under acidic conditions, CBD can be

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An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.

Related Articles An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis Cannabinoid Res. 2017;2(1):139-154 Authors: Iffland K, Grotenhermen F Abstract Introduction: This literature survey aims to extend the comprehensive survey performed by Bergamaschi et al. in 2011 on cannabidiol (CBD) safety and side effects. Apart

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Cannabis and Pain: A Clinical Review.

Related Articles Cannabis and Pain: A Clinical Review. Cannabis Cannabinoid Res. 2017;2(1):96-104 Authors: Hill KP, Palastro MD, Johnson B, Ditre JW Abstract Introduction: Cannabis has been used for medical purposes across the world for centuries. As states and countries implement medical and recreational cannabis policies, increasing numbers of people are using cannabis pharmacotherapy for pain.

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Training and Practices of Cannabis Dispensary Staff.

Related Articles Training and Practices of Cannabis Dispensary Staff. Cannabis Cannabinoid Res. 2016;1(1):244-251 Authors: Haug NA, Kieschnick D, Sottile JE, Babson KA, Vandrey R, Bonn-Miller MO Abstract Introduction: The proliferation of cannabis dispensaries within the United States has emerged from patient demand for the legalization of cannabis as an alternative treatment for a number of

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Marijuana for “Anxiety-Tension”

An excerpt from Smoke Signals: A Social History of Marijuana – Medical, Recreational and Scientific by Martin A. Lee Powered by WPeMatico

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Terpene synthases from Cannabis sativa.

Related Articles Terpene synthases from Cannabis sativa. PLoS One. 2017;12(3):e0173911 Authors: Booth JK, Page JE, Bohlmann J Abstract Cannabis (Cannabis sativa) plants produce and accumulate a terpene-rich resin in glandular trichomes, which are abundant on the surface of the female inflorescence. Bouquets of different monoterpenes and sesquiterpenes are important components of cannabis resin as they

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Cannabis Use During Pregnancy: Is it Safe?

Pamela is newly pregnant with her third child. She and her husband think this is going to be their last one because she is having a dreadful time with nausea – morning sickness that lasts all day long. She knows all the tricks. Saltines by her bedside, taking Vitamin B6 and B12, and eating frequently

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The potential role of cannabinoids in epilepsy treatment.

The potential role of cannabinoids in epilepsy treatment. Expert Rev Neurother. 2017 Aug 26;: Authors: De Caro C, Leo A, Citraro R, De Sarro C, Russo R, Calignano A, Russo E Abstract INTRODUCTION: Epilepsy is one of the world’s oldest recognized and prevalent neurological diseases. It has a great negative impact on patients’ quality of

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Cannabinoids as Anticancer Drugs.

Related Articles Cannabinoids as Anticancer Drugs. Adv Pharmacol. 2017;80:397-436 Authors: Ramer R, Hinz B Abstract The endocannabinoid system encompassing cannabinoid receptors, endogenous receptor ligands (endocannabinoids), as well as enzymes conferring the synthesis and degradation of endocannabinoids has emerged as a considerable target for pharmacotherapeutical approaches of numerous diseases. Besides palliative effects of cannabinoids used in

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Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads.

Related Articles Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads. Adv Pharmacol. 2017;80:67-134 Authors: Russo EB, Marcu J Abstract The golden age of cannabis pharmacology began in the 1960s as Raphael Mechoulam and his colleagues in Israel isolated and synthesized cannabidiol, tetrahydrocannabinol, and other phytocannabinoids. Initially, THC garnered most research interest with sporadic

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Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels.

Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels. Epilepsy Behav. 2017 Aug 15;75:29-35 Authors: Vilela LR, Lima IV, Kunsch ÉB, Pinto HPP, de Miranda AS, Vieira ÉLM, de Oliveira ACP, Moraes MFD, Teixeira AL, Moreira FA Abstract Cannabidiol (CBD), the main nonpsychotomimetic compound from Cannabis sativa, inhibits

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GPR55: A therapeutic target for Parkinson’s disease?

Related Articles GPR55: A therapeutic target for Parkinson’s disease? Neuropharmacology. 2017 Aug 11;: Authors: Celorrio M, Rojo-Bustamante E, Fernández-Suárez D, Sáez E, Estella-Hermoso de Mendoza A, Müller CE, Ramírez MJ, Oyarzábal J, Franco R, Aymerich MS Abstract The GPR55 receptor is expressed abundantly in the brain, especially in the striatum, suggesting it might fulfill a

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Antiepileptic drugs in clinical development: differentiate or die?

Related Articles Antiepileptic drugs in clinical development: differentiate or die? Curr Pharm Des. 2017 Aug 09;: Authors: Zaccara G, Schmidt D Abstract BACKGROUND: Animal models when carefully selected, designed and conducted, are important parts of any translational drug development strategy. However, research of new compounds for patients with drug-resistant epilepsies is still based on animal

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Safety profile of the newest antiepileptic drugs: a curated literature review.

Related Articles Safety profile of the newest antiepileptic drugs: a curated literature review. Curr Pharm Des. 2017 Aug 09;: Authors: Palleria C, Cozza G, Khengar R, Libri V, De Sarro G Abstract BACKGROUND: Despite the introduction of new antiepileptic drugs (AEDs), the quality of life and therapeutic response for patients with epilepsy remain unsatisfactory. In

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Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid.

Related Articles Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid. Int J Mol Sci. 2017 Jul 31;18(8): Authors: Kozela E, Juknat A, Vogel Z Abstract The astrocytes have gained in recent decades an enormous interest as a potential target for neurotherapies, due to their essential and pleiotropic roles in brain physiology and pathology. Their

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Evaluation of Oxidant/Antioxidant Status and Cytokine Levels in Patients with Cannabis Use Disorder.

Related Articles Evaluation of Oxidant/Antioxidant Status and Cytokine Levels in Patients with Cannabis Use Disorder. Clin Psychopharmacol Neurosci. 2017 Aug 31;15(3):237-242 Authors: Bayazit H, Selek S, Karababa IF, Cicek E, Aksoy N Abstract Objective: Cannabis is the most commonly used illegal drug in the world and it has several adverse effects such as anxiety, panic

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Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies.

Related Articles Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies. Br J Pain. 2017 Aug;11(3):119-133 Authors: Fallon MT, Albert Lux E, McQuade R, Rossetti S, Sanchez R, Sun W, Wright S, Lichtman AH, Kornyeyeva E Abstract BACKGROUND: Opioids

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Interactions between cannabidiol and commonly used antiepileptic drugs.

Related Articles Interactions between cannabidiol and commonly used antiepileptic drugs. Epilepsia. 2017 Aug 06;: Authors: Gaston TE, Bebin EM, Cutter GR, Liu Y, Szaflarski JP, UAB CBD Program Abstract OBJECTIVE: To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs (AEDs) through an open-label safety study.

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Could Cannabidiol be a Treatment Option for Intractable Childhood and Adolescent Epilepsy?

Related Articles Could Cannabidiol be a Treatment Option for Intractable Childhood and Adolescent Epilepsy? J Epilepsy Res. 2017 Jun;7(1):16-20 Authors: Koo CM, Kang HC Abstract Epilepsy is an important disease that affects brain function, particularly in those under 3 years old. Uncontrolled seizures can affect cognitive function and quality of life. For these reasons, many

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CBD for Fibromyalgia and Opioid Withdrawal

I wanted to relay the experience I’m having with CBD aiding opiate withdrawal. I am a 72-year-old woman. A doctor put me on fentanyl patches about 10 years ago, after trying various painkillers for my intense fibromyalgia pain. They did not notify me how difficult, if not impossible, it would be to get off of

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ICRS 2017: Report from Montreal

During the last week of June, more than 400 scientists from 25 countries met in Montreal for the 27th annual symposium of the International Cannabinoid Research Society (ICRS). Several presentations and posters showcased new findings about cannabidiol (CBD), the non-euphoric component of the cannabis plant that is transforming the medical marijuana landscape. Powered by WPeMatico

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Fewer Seizures With Cannabidiol in Catastrophic Epilepsy.

Related Articles Fewer Seizures With Cannabidiol in Catastrophic Epilepsy. JAMA. 2017 Jul 25;318(4):323 Authors: Slomski A PMID: 28742905 [PubMed – in process] Powered by WPeMatico

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Endocannabinoids in arthritis: current views and perspective.

Related Articles Endocannabinoids in arthritis: current views and perspective. Int J Rheum Dis. 2017 Jul;20(7):789-797 Authors: Barrie N, Kuruppu V, Manolios E, Ali M, Moghaddam M, Manolios N Abstract Preclinical and clinical studies using cannabis-based therapy have been shown to provide both analgesia and anti-inflammatory effects, with an overall alleviation of clinical symptoms in animal

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Effects of antiepileptic drugs on mitochondrial functions, morphology, kinetics, biogenesis, and survival.

Effects of antiepileptic drugs on mitochondrial functions, morphology, kinetics, biogenesis, and survival. Epilepsy Res. 2017 Jul 13;136:5-11 Authors: Finsterer J, Scorza FA Abstract OBJECTIVES: Antiepileptic drugs (AEDs) exhibit adverse and beneficial effects on mitochondria, which have a strong impact on the treatment of patients with a mitochondrial disorder (MID) with epilepsy (mitochondrial epilepsy). This review

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Cannabis: an overview of its adverse acute and chronic effects and their implications.

Cannabis: an overview of its adverse acute and chronic effects and their implications. Curr Drug Abuse Rev. 2017 Jul 12;: Authors: Ford TC, Hayley AC, Downey LA, Parrott AC Abstract In many communities, cannabis is perceived as a low-risk drug, leading to political lobbying to decriminalise its use. However, acute and chronic cannabis use has

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CBD and Parkinson’s Disease

Scientists at the University of Louisville School of Medicine in Kentucky have identified a previously unknown molecular target of cannabidiol (CBD), which may have significant therapeutic implications for Parkinson’s Disease (PD). Powered by WPeMatico

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An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol.

Related Articles An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol. Front Pharmacol. 2017;8:422 Authors: Morales P, Reggio PH, Jagerovic N Abstract Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis. Currently, CBD generates

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Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?

Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients? Expert Opin Ther Targets. 2017 Jul 07;: Authors: Nijs J, Loggia ML, Polli A, Moens M, Huysmans E, Goudman L, Meeus M, Vanderweeën L, Ickmans K, Clauw D Abstract INTRODUCTION: The mechanism of sensitization of the central

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Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats.

Related Articles Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats. Front Pharmacol. 2017;8:391 Authors: Genaro K, Fabris D, Arantes ALF, Zuardi AW, Crippa JAS, Prado WA Abstract Background: Pain involves different brain regions and is critically determined by emotional processing. Among other areas, the rostral anterior cingulate cortex (rACC)

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Suppression of invasion and metastasis in aggressive salivary cancer cells through targeted inhibition of ID1 gene expression.

Related Articles Suppression of invasion and metastasis in aggressive salivary cancer cells through targeted inhibition of ID1 gene expression. Cancer Lett. 2016 Jul 10;377(1):11-6 Authors: Murase R, Sumida T, Kawamura R, Onishi-Ishikawa A, Hamakawa H, McAllister SD, Desprez PY Abstract Salivary gland cancer (SGC) represents the most common malignancy in the head and neck region,

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Marijuana for the Masses

It’s been 50 years since the fabled “Summer of Love” in San Francisco. The City by the Bay was the epicenter of a countercultural uprising fueled by cannabis and LSD, which happened so vividly and with such intensity that it generated worldwide attention. Powered by WPeMatico

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Cannabinoids in Pediatrics.

Related Articles Cannabinoids in Pediatrics. J Pediatr Pharmacol Ther. 2017 May-Jun;22(3):176-185 Authors: Campbell CT, Phillips MS, Manasco K Abstract Despite its controversial nature, the use of medical marijuana and cannabis-derived medicinal products grows more popular with each passing year. As of November 2016, over 40 states have passed legislation regarding the use of either medical

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Assessing the role of serotonergic receptors in cannabidiol’s anticonvulsant efficacy.

Assessing the role of serotonergic receptors in cannabidiol’s anticonvulsant efficacy. Epilepsy Behav. 2017 Jun 15;73:111-118 Authors: Pelz MC, Schoolcraft KD, Larson C, Spring MG, López HH Abstract Cannabidiol (CBD) is a phytocannabinoid that has demonstrated anticonvulsant efficacy in several animal models of seizure. The current experiment validated CBD’s anticonvulsant effect using the acute pentylenetetrazol (PTZ)

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Epilepsy: Cannabidiol reduces seizure frequency in Dravet syndrome.

Related Articles Epilepsy: Cannabidiol reduces seizure frequency in Dravet syndrome. Nat Rev Neurol. 2017 Jun 09;: Authors: Ridler C PMID: 28621765 [PubMed – as supplied by publisher] Powered by WPeMatico

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Quality of Life in Childhood Epilepsy in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol.

Quality of Life in Childhood Epilepsy in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol. Epilepsia. 2017 Jun 15;: Authors: Rosenberg EC, Louik J, Conway E, Devinsky O, Friedman D Abstract Recent clinical trials indicate that cannabidiol (CBD) may reduce seizure frequency in pediatric patients with certain forms of treatment-resistant epilepsy. Many

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Project CBD Responds to California’s Proposed Testing Requirements

Our organization outlines our concerns with the State of California’s proposed regulations for cannabis testing regarding pesticides, heavy metals, and solvents and our recommendations for amending them. We believe the following recommendations will benefit patients, recreational users, and people working in the industry. Powered by WPeMatico

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Many Animals Know How to Self-Medicate

Humans aren’t the only species who know how to ingest medicinal plants for their health. Discover the botanical remedies that other animals take, and why they have evolved to do so. Powered by WPeMatico

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Cannabis & Spirituality

The genus Cannabis has been seen and felt as a being, or a deity, in multiple cultures. This book excerpt by Kathleen Harrison discusses some of the historical cultural and spiritual uses of the cannabis plant across the globe. Powered by WPeMatico

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Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways.

Related Articles Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways. Oncotarget. 2017 May 27;: Authors: Ivanov VN, Wu J, Hei TK Abstract Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The challenging problem in cancer treatment is to find

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Cannabis and intractable chronic pain: an explorative retrospective analysis of Italian cohort of 614 patients.

Cannabis and intractable chronic pain: an explorative retrospective analysis of Italian cohort of 614 patients. J Pain Res. 2017;10:1217-1224 Authors: Fanelli G, De Carolis G, Leonardi C, Longobardi A, Sarli E, Allegri M, Schatman ME Abstract BACKGROUND: Despite growing interest in the therapeutic use of cannabis to manage chronic pain, only limited data that address

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Single and combined effects of delta(9) -tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain.

Single and combined effects of delta(9) -tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain. Br J Pharmacol. 2017 May 26;: Authors: King KM, Myers AM, Soroka-Monzo AJ, Tuma RF, Tallarida RJ, Walker EA, Ward SJ Abstract BACKGROUND AND PURPOSE: It has been suggested that the non-psychoactive phytocannabinoid cannabidiol (CBD) can impact the

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Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome.

Related Articles Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome. N Engl J Med. 2017 05 25;376(21):2011-2020 Authors: Devinsky O, Cross JH, Laux L, Marsh E, Miller I, Nabbout R, Scheffer IE, Thiele EA, Wright S, Cannabidiol in Dravet Syndrome Study Group Abstract BACKGROUND: The Dravet syndrome is a complex childhood epilepsy disorder

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Dosing THCA: Less is more

THCA (tetrahydrocannabinolic acid) is the non-psychoactive acid form of THC found in the plant when raw. THCA converts to THC when it is decarboxylated. Discover the clinical and laboratory research on THCA for epilepsy, chronic pain, digestive disorders, and more. Powered by WPeMatico

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Who Is She?

The genus Cannabis has been seen and felt as a being, or a deity, in multiple cultures. This book excerpt by Kathleen Harrison discusses some of the historical cultural and spiritual uses of the cannabis plant across the globe. Powered by WPeMatico

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Cannabidiol in Medical Marijuana: Research Vistas and Potential Opportunities.

Related Articles Cannabidiol in Medical Marijuana: Research Vistas and Potential Opportunities. Pharmacol Res. 2017 May 10;: Authors: Rong C, Lee Y, Carmona NE, Cha DS, Ragguett RM, Rosenblat JD, Mansur RB, Ho RC, McIntyre RS Abstract The high and increasing prevalence of medical marijuana consumption in the general population invites the need for quality evidence

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Cannabidiol in Patients With Intractable Epilepsy Due to TSC: A Possible Medication But Not a Miracle.

Related Articles Cannabidiol in Patients With Intractable Epilepsy Due to TSC: A Possible Medication But Not a Miracle. Epilepsy Curr. 2017 Mar-Apr;17(2):91-92 Authors: Nickels K PMID: 28490996 [PubMed – in process] Powered by WPeMatico

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Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP).

Related Articles Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP). Neurochem Res. 2017 May 06;: Authors: Klein BD, Jacobson CA, Metcalf CS, Smith MD, Wilcox KS, Hampson AJ, Kehne JH Abstract Cannabidiol (CBD) is a cannabinoid component of marijuana that has no significant activity at cannabinoid receptors or psychoactive

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Burning Issue: Cannabis Pesticide Regulations Need Rethink

Pesticide use in the cannabis industry is a widespread issue. Two common pesticides used in marijuana, Eagle 20 and pyrethrins, highlight the inconsistency of current pesticide regulations. Learn why It is paramount to study the effects of heating pesticides and their present and longterm effects.​ Powered by WPeMatico

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Comparative in silico analyses of Cannabis sativa, Prunella vulgaris and Withania somnifera compounds elucidating the medicinal properties against rheumatoid arthritis.

Related Articles Comparative in silico analyses of Cannabis sativa, Prunella vulgaris and Withania somnifera compounds elucidating the medicinal properties against rheumatoid arthritis. J Mol Graph Model. 2017 Apr 19;74:296-304 Authors: Zaka M, Sehgal SA, Shafique S, Abbasi BH Abstract From last decade, there has been progressive improvement in computational drug designing. Several diseases are being

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Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions.

Related Articles Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions. Neuropsychiatr Dis Treat. 2017;13:1131-1140 Authors: Ostendorf AP, Ng YT Abstract Lennox-Gastaut syndrome is a severe, childhood-onset electroclinical syndrome comprised of multiple seizure types, intellectual and behavioral disturbances and characteristic findings on electroencephalogram of slow spike and wave complexes and paroxysmal fast frequency activity. Profound

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Short-Term Efficacy of CBD-Enriched Hemp Oil in Girls with Dysautonomic Syndrome after Human Papillomavirus Vaccination.

Short-Term Efficacy of CBD-Enriched Hemp Oil in Girls with Dysautonomic Syndrome after Human Papillomavirus Vaccination. Isr Med Assoc J. 2017 Feb;19(2):79-84 Authors: Palmieri B, Laurino C, Vadalà M Abstract BACKGROUND: Cannabidiol (CBD)-based treatments for several diseases, including Tourette’s syndrome, multiple sclerosis, epilepsy, movement disorders and glaucoma, are proving to be beneficial and the scientific clinical

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Cannabidiol Treatment for Refractory Seizures in Sturge-Weber Syndrome.

Related Articles Cannabidiol Treatment for Refractory Seizures in Sturge-Weber Syndrome. Pediatr Neurol. 2017 Feb 22;: Authors: Kaplan EH, Offermann EA, Sievers JW, Comi AM Abstract BACKGROUND: Sturge-Weber syndrome results in leptomeningeal vascular malformations, medically refractory epilepsy, stroke(s), and cognitive impairments. Cannabidiol, a cannabinoid without psychoactive properties, has been demonstrated in preclinical models to possibly have

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Cannabidiol-Δ(9)-tetrahydrocannabinol interactions on acute pain and locomotor activity.

Cannabidiol-Δ(9)-tetrahydrocannabinol interactions on acute pain and locomotor activity. Drug Alcohol Depend. 2017 Apr 15;175:187-197 Authors: Britch SC, Wiley JL, Yu Z, Clowers BH, Craft RM Abstract BACKGROUND: Previous studies suggest that cannabidiol (CBD) may potentiate or antagonize Δ(9)-tetrahydrocannabinol’s (THC) effects. The current study examined sex differences in CBD modulation of THC-induced antinociception, hypolocomotion, and metabolism.

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[Cannabis as a therapeutic agent: Focal topic].

Related Articles [Cannabis as a therapeutic agent: Focal topic]. Schmerz. 2016 Feb;30(1):1-2 Authors: Radbruch L, Schäfer M PMID: 26809973 [PubMed – indexed for MEDLINE] Powered by WPeMatico

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Claws and Effect: Cannabis Medicine for Pets

Any animal with a backbone (classified as a chordate) has an endocannabinoid system. The Kingdom of Chordata includes amphibians, reptiles, birds, fish, and mammals, including house pets. Many animal-owners treat their beloved pets like family members. When a dog or a cat gets sick and conventional options don’t work, people seek alternatives. In the realm

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Neurological aspects of medical use of cannabidiol.

Related Articles Neurological aspects of medical use of cannabidiol. CNS Neurol Disord Drug Targets. 2017 Apr 13;: Authors: Mannucci C, Navarra M, Calapai F, Spagnolo EV, Busardò FP, Da Cas R, Ippolito FM, Calapai G Abstract BACKGROUND: Cannabidiol (CBD) is among the major secondary metabolites of Cannabis devoid of the delta-9-tetra-hydrocannabinol psychoactive effects. It is

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Neuropsychiatric and general interactions of natural and synthetic cannabinoids with drugs of abuse and medicines.

Related Articles Neuropsychiatric and general interactions of natural and synthetic cannabinoids with drugs of abuse and medicines. CNS Neurol Disord Drug Targets. 2017 Apr 13;: Authors: Arellano AL, Papaseit E, Romaguera A, Torrens M, Farré M Abstract Cannabis is the most widely used illicit drug. The two most important natural cannabinoids are delta-9-tetrahydrocannabinol (THC) and

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Anti-neuroinflammatory effects of grossamide from hemp seed via suppression of TLR-4-mediated NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells.

Related Articles Anti-neuroinflammatory effects of grossamide from hemp seed via suppression of TLR-4-mediated NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells. Mol Cell Biochem. 2017 Apr;428(1-2):129-137 Authors: Luo Q, Yan X, Bobrovskaya L, Ji M, Yuan H, Lou H, Fan P Abstract Grossamide, a representative lignanamide in hemp seed, has been reported to possess potential

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Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy.

Related Articles Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy. Neurol Res Int. 2017;2017:2985729 Authors: Aguirre-Velázquez CG Abstract Structured online surveys were used to explore the experiences of the parents of children with refractory epilepsy using medicinal cannabis in Mexico during September 2016. The

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Cannabinoids as hippocampal network administrators.

Related Articles Cannabinoids as hippocampal network administrators. Neuropharmacology. 2017 Apr 06;: Authors: Lupica CR, Hu Y, Devinsky O, Hoffman AF Abstract Extensive pioneering studies performed in the hippocampus have greatly contributed to our knowledge of an endogenous cannabinoid system comprised of the molecular machinery necessary to process these endocannabinoid lipid messengers and their associated cannabinoid

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Cannabidiol Reduces Leukemic Cell Size – But Is It Important?

Related Articles Cannabidiol Reduces Leukemic Cell Size – But Is It Important? Front Pharmacol. 2017;8:144 Authors: Kalenderoglou N, Macpherson T, Wright KL Abstract The anti-cancer effect of the plant-derived cannabinoid, cannabidiol, has been widely demonstrated both in vivo and in vitro. However, this body of preclinical work has not been translated into clinical use. Key

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Update: Toxic Vape Oil Additives Endanger Patients

Vaporizer pens are a trendy and discrete manner to vaporize cannabis medicine. However, commonly used thinning agent in many products on the market are harmful when heated and inhaled. Powered by WPeMatico

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In or Out? Sungrown vs. Indoor Cannabis Cultivation

Which growing method produces better cannabis – sungrown, indoors, or greenhouse? Here is a breakdown of the pros and cons. Powered by WPeMatico

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Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy.

Related Articles Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy. Front Pharmacol. 2017;8:131 Authors: Do Val-da Silva RA, Peixoto-Santos JE, Kandratavicius L, De Ross JB, Esteves I, De Martinis BS, Alves MN, Scandiuzzi RC, Hallak JE, Zuardi AW, Crippa JA, Leite JP Abstract The present

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Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn's Disease, a Randomized Controlled Trial.

Related Articles Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn’s Disease, a Randomized Controlled Trial. Dig Dis Sci. 2017 Mar 27;: Authors: Naftali T, Mechulam R, Marii A, Gabay G, Stein A, Bronshtain M, Laish I, Benjaminov F, Konikoff FM Abstract BACKGROUND: Cannabidiol (CBD) is an anti-inflammatory cannabinoid shown to be

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Cannabis, Cannabinoids, and Sleep: a Review of the Literature.

Related Articles Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Curr Psychiatry Rep. 2017 Apr;19(4):23 Authors: Babson KA, Sottile J, Morabito D Abstract PURPOSE OF REVIEW: The current review aims to summarize the state of research on cannabis and sleep up to 2014 and to review in detail the literature on cannabis and specific

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Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?

Related Articles Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids? Front Pharmacol. 2017;8:108 Authors: Brand EJ, Zhao Z Abstract Cannabis sativa L. (Cannabaceae) has a long history of utilization as a fiber and seed crop in China, and its achenes (“seeds”) as well as other plant parts have

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Recipe: DNA-Repairing Pumpkin Curry

Food is medicine. This delicious pumpkin curry recipe by Nature Going Smart is full of ingredients with powerful healing properties. Powered by WPeMatico

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Diet & the Endocannabinoid System

The endocannabinoid system regulates numerous physiological processes, including intestinal function, glucose metabolism, and the stress response. New research discusses the roles of CB1 and CB2 cannabinoid receptors pertaining to diet, digestion, and energy metabolism. Powered by WPeMatico

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Cannabis for Pain and Headaches: Primer.

Related Articles Cannabis for Pain and Headaches: Primer. Curr Pain Headache Rep. 2017 Apr;21(4):19 Authors: Kim PS, Fishman MA Abstract PURPOSE OF REVIEW: Marijuana has been used both medicinally and recreationally since ancient times and interest in its compounds for pain relief has increased in recent years. The identification of our own intrinsic, endocannabinoid system

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Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go?

Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go? Expert Rev Gastroenterol Hepatol. 2017 Feb 16;:1-9 Authors: Hasenoehrl C, Storr M, Schicho R Abstract INTRODUCTION: Fifty years after the discovery of Δ(9)-tetrahydrocannabinol (THC) as the psychoactive component of Cannabis, we are assessing the possibility of translating this herb into clinical

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Cannabinoids therapeutic use: what is our current understanding following the introduction of THC, THC:CBD oromucosal spray and others?

Cannabinoids therapeutic use: what is our current understanding following the introduction of THC, THC:CBD oromucosal spray and others? Expert Rev Clin Pharmacol. 2017 Feb 28;:1-13 Authors: Maccarrone M, Maldonado R, Casas M, Henze T, Centonze D Abstract INTRODUCTION: The complexity of the endocannabinoid (eCB) system is becoming better understood and new drivers of eCB signaling

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The current status of artisanal cannabis for the treatment of epilepsy in the United States.

Related Articles The current status of artisanal cannabis for the treatment of epilepsy in the United States. Epilepsy Behav. 2017 Feb 18;: Authors: Sulak D, Saneto R, Goldstein B Abstract The widespread patient use of artisanal cannabis preparations has preceded quality validation of cannabis use for epilepsy. Neurologists and cannabinoid specialists are increasingly in a

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Potential of Cannabidiol for the Treatment of Viral Hepatitis.

Related Articles Potential of Cannabidiol for the Treatment of Viral Hepatitis. Pharmacognosy Res. 2017 Jan-Mar;9(1):116-118 Authors: Lowe HI, Toyang NJ, McLaughlin W Abstract Viral hepatitis B (HBV) and hepatitis C (HCV) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer. While HBV

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Medical Marijuana for Seizures

A cutting edge paper from three cannabis friendly medical professionals— Dustin Sulak, Russel Saneto, and Bonni Goldstein— outlines case reports and the applications of cannabis medicine for epilepsy and seizure disorders. Powered by WPeMatico

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In or Out?

Which growing method produces better cannabis – sungrown, indoors, or greenhouse? Here is a breakdown of the pros and cons. Powered by WPeMatico

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Refractory trigeminal neuralgia responsive to nabiximols in a patient with multiple sclerosis.

Related Articles Refractory trigeminal neuralgia responsive to nabiximols in a patient with multiple sclerosis. Mult Scler Relat Disord. 2016 Jul;8:64-5 Authors: Gajofatto A Abstract INTRODUCTION: Nabiximols is a cannabinoid compound approved for the treatment of multiple sclerosis (MS)-related spasticity. However, additional symptoms, such as pain, urinary urgency and sleep disturbance, may benefit from treatment. CASE

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Social correlates of health status, quality of life, and mood states in patients treated with cannabidiol for epilepsy.

Related Articles Social correlates of health status, quality of life, and mood states in patients treated with cannabidiol for epilepsy. Epilepsy Behav. 2017 Feb 21;: Authors: Szaflarski M, Hansen B, Bebin EM, Szaflarski JP Abstract Social characteristics, such as socioeconomic status and race/ethnicity, play a role in the treatment and outcomes of patients with epilepsy

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Chronic low-grade peripheral inflammation is associated with severe nicotine dependence in schizophrenia: results from the national multicentric FACE-SZ cohort.

Chronic low-grade peripheral inflammation is associated with severe nicotine dependence in schizophrenia: results from the national multicentric FACE-SZ cohort. Eur Arch Psychiatry Clin Neurosci. 2017 Feb 25;: Authors: Fond G, Berna F, Andrianarisoa M, Godin O, Leboyer M, Brunel L, Aouizerate B, Capdevielle D, Chereau I, D’Amato T, Denizot H, Dubertret C, Dubreucq J, Faget

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Cannabidiol: State of the art and new challenges for therapeutic applications.

Related Articles Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacol Ther. 2017 Feb 20;: Authors: Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M, Faggiana G, Proto MC, Fiore D, Laezza C, Bifulco M Abstract Over the past years, several lines of evidence support a therapeutic

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Improved Social Interaction, Recognition and Working Memory with Cannabidiol Treatment in a Prenatal Infection (poly I:C) Rat Model.

Related Articles Improved Social Interaction, Recognition and Working Memory with Cannabidiol Treatment in a Prenatal Infection (poly I:C) Rat Model. Neuropsychopharmacology. 2017 Feb 23;: Authors: Osborne AL, Solowij N, Babic I, Huang XF, Weston-Green K Abstract Neuropsychiatric disorders such as schizophrenia are associated with cognitive impairment, including learning, memory and attention deficits. Antipsychotic drugs are

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In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease.

Related Articles In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer’s Disease. Front Pharmacol. 2017;8:20 Authors: Watt G, Karl T Abstract Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that is affecting an increasing number of people. It is characterized by the accumulation of amyloid-β and tau hyperphosphorylation as well as neuroinflammation and

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Cannabis cultivation: Methodological issues for obtaining medical-grade product.

Related Articles Cannabis cultivation: Methodological issues for obtaining medical-grade product. Epilepsy Behav. 2017 Feb 12;: Authors: Chandra S, Lata H, ElSohly MA, Walker LA, Potter D Abstract As studies continue to reveal favorable findings for the use of cannabidiol in the management of childhood epilepsy syndromes and other disorders, best practices for the large-scale production

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Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?

Related Articles Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis? Neural Regen Res. 2016 Dec;11(12):1896-1899 Authors: Giacoppo S, Mazzon E Abstract Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic

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Evaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil by ultra-high performance liquid chromatography tandem mass spectrometry.

Evaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil by ultra-high performance liquid chromatography tandem mass spectrometry. Clin Chem Lab Med. 2017 Feb 16;: Authors: Pacifici R, Marchei E, Salvatore F, Guandalini L, Busardò FP, Pichini S Abstract BACKGROUND: Cannabis has been used since ancient times to relieve neuropathic

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Gut Check

Project CBD exposes fraud and financial interests behind misleading report suggesting that CBD converts to THC in the stomach. Powered by WPeMatico

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CBD: The Cinderella Molecule

High Times article by Martin A Lee highlights the breakthrough research on CBD, and how it has revolutionized the story of cannabis medicine. Powered by WPeMatico

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Treatment of Dravet Syndrome.

Related Articles Treatment of Dravet Syndrome. Can J Neurol Sci. 2016 Jun;43 Suppl 3:S13-8 Authors: Wirrell EC Abstract Dravet syndrome is among the most challenging electroclinical syndromes. There is a high likelihood of recurrent status epilepticus; seizures are medically refractory; and patients have multiple co-morbidities, including intellectual disability, behaviour and sleep problems, and crouch gait.

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Mind Over Matter Over Mind

The placebo effect happens when an expectation of benefit in a treatment creates the same response as an actual treatment. How does the power of thought influence the endocannabinoid system and our health? Powered by WPeMatico

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Ultra-high performance liquid chromatography tandem mass-spectrometry for simple and simultaneous quantification of cannabinoids.

Related Articles Ultra-high performance liquid chromatography tandem mass-spectrometry for simple and simultaneous quantification of cannabinoids. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Feb 06;1048:10-18 Authors: Jamwal R, Topletz AR, Ramratnam B, Akhlaghi F Abstract Cannabis is used widely in the United States, both recreationally and for medical purposes. Current methods for analysis of

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Cannabidiol: an alternative therapeutic agent for oral mucositis?

Related Articles Cannabidiol: an alternative therapeutic agent for oral mucositis? J Clin Pharm Ther. 2017 Feb 12;: Authors: Cuba LF, Salum FG, Cherubini K, Figueiredo MA Abstract WHAT IS KNOWN AND OBJECTIVE: Chemo- and radiotherapy are therapeutic modalities often used in patients with malignant neoplasms. They kill tumour cells but act on healthy tissues as

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Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection.

Related Articles Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection. Epilepsy Behav. 2017 Feb 09;: Authors: Rosenberg EC, Patra PH, Whalley BJ Abstract The isolation and identification of the discrete plant cannabinoids in marijuana revived interest in analyzing historical therapeutic claims made for cannabis in clinical case studies and

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Treatment issues for children with epilepsy transitioning to adult care.

Treatment issues for children with epilepsy transitioning to adult care. Epilepsy Behav. 2017 Feb 07;: Authors: Nabbout R, Camfield CS, Andrade DM, Arzimanoglou A, Chiron C, Cramer JA, French JA, Kossoff E, Mula M, Camfield PR Abstract This is the third of three papers that summarize the second symposium on Transition in Epilepsies held in

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Cannabinoids in treatment-resistant epilepsy: A review.

Cannabinoids in treatment-resistant epilepsy: A review. Epilepsy Behav. 2017 Feb 07;: Authors: O’Connell BK, Gloss D, Devinsk O Abstract Treatment-resistant epilepsy (TRE) affects 30% of epilepsy patients and is associated with severe morbidity and increased mortality. Cannabis-based therapies have been used to treat epilepsy for millennia, but only in the last few years have we

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The legal status of cannabis (marijuana) and cannabidiol (CBD) under U.S. law.

Related Articles The legal status of cannabis (marijuana) and cannabidiol (CBD) under U.S. law. Epilepsy Behav. 2017 Feb 03;: Authors: Mead A Abstract In the United States, federal and state laws regarding the medical use of cannabis and cannabinoids are in conflict and have led to confusion among patients, caregivers, and healthcare providers. Currently, cannabis

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Complementary Therapies in Inflammatory Bowel Diseases.

Related Articles Complementary Therapies in Inflammatory Bowel Diseases. Curr Gastroenterol Rep. 2016 Dec;18(12):62 Authors: Yanai H, Salomon N, Lahat A Abstract Inflammatory bowel diseases (IBDs) often take a chronic debilitating course. Given the chronicity of IBD, the limitations of the available medications, their potential side effects, and the impact of the disease on patients’ quality

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Project CBD Launches Spanish-Language Website

Project CBD has launched our Spanish language website so that 427 million native speakers across the world will have access to health positive news on cannabis therapeutics. Powered by WPeMatico

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Mind Over Matter Over Mind: Endocannabinoids & the Placebo Effect

The placebo effect happens when an expectation of benefit in a treatment creates the same response as an actual treatment. How does the power of thought influence the endocannabinoid system and our health? Powered by WPeMatico

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[There is evidence for the use of cannabinoids for symptomatic treatment of multiple sclerosis].

Related Articles [There is evidence for the use of cannabinoids for symptomatic treatment of multiple sclerosis]. Ugeskr Laeger. 2015 May 11;177(20):956-60 Authors: Bazinski H, Jensen HB, Stenager E Abstract We identified 16 randomized placebo-controlled trials investigating cannabinoids as symptomatic treatment in multiple sclerosis (MS). There is evidence that nabiximols oromucosal spray may reduce subjective symptoms

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Phytochemistry of Cannabis sativa L.

Related Articles Phytochemistry of Cannabis sativa L. Prog Chem Org Nat Prod. 2017;103:1-36 Authors: ElSohly MA, Radwan MM, Gul W, Chandra S, Galal A Abstract Cannabis (Cannabis sativa, or hemp) and its constituents-in particular the cannabinoids-have been the focus of extensive chemical and biological research for almost half a century since the discovery of the

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Targeting calcium signaling in cancer therapy.

Related Articles Targeting calcium signaling in cancer therapy. Acta Pharm Sin B. 2017 Jan;7(1):3-17 Authors: Cui C, Merritt R, Fu L, Pan Z Abstract The intracellular calcium ions (Ca(2+)) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca(2+) homeostasis is altered in cancer cells

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Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII).

Related Articles Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII). Epilepsia. 2017 Jan 23;: Authors: Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS Abstract The Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII) took place

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Neuroimaging studies towards understanding the central effects of pharmacological cannabis products on patients with epilepsy.

Related Articles Neuroimaging studies towards understanding the central effects of pharmacological cannabis products on patients with epilepsy. Epilepsy Behav. 2017 Jan 18;: Authors: Allendorfer JB, Szaflarski JP Abstract Recent interest for the use of cannabis-derived products as therapeutic agents in the treatment of epilepsies has necessitated a reevaluation of their effects on brain and behavior.

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Migraine Headaches

While it has been demonstrated that marijuana may help to alleviate migraine headaches, the mechanisms of how it does so is relatively unknown. Dr. Bonni Goldstein highlights current research about the applications for cannabinoid medicine for severe headaches and shares a patient testimony of a mother who found relief from her migraines using THC dominant

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The Society of Cannabis Clinicians critiques AMA guidelines for state medical boards

The Society of Cannabis Clinicians calls on the medical board for more sensible policies towards cannabis, which includes collaboration with medical cannabis dispensaries as well as removing the stigma of cannabis as a substance of abuse. Powered by WPeMatico

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Historical perspective on the medical use of cannabis for epilepsy: Ancient times to the 1980s.

Related Articles Historical perspective on the medical use of cannabis for epilepsy: Ancient times to the 1980s. Epilepsy Behav. 2017 Jan 11;: Authors: Friedman D, Sirven JI Abstract There has been a dramatic surge in the interest of utilizing cannabis for epilepsy treatment in the US. Yet, access to cannabis for research and therapy is

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Cannabidiol Claims and Misconceptions.

Related Articles Cannabidiol Claims and Misconceptions. Trends Pharmacol Sci. 2017 Jan 11;: Authors: Russo EB Abstract Once a widely ignored phytocannabinoid, cannabidiol now attracts great therapeutic interest, especially in epilepsy and cancer. As with many rising trends, various myths and misconceptions have accompanied this heightened public interest and intrigue. This forum article examines and attempts

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Pharmacology of cannabinoids in the treatment of epilepsy.

Related Articles Pharmacology of cannabinoids in the treatment of epilepsy. Epilepsy Behav. 2017 Jan 10;: Authors: Gaston TE, Friedman D Abstract The use of cannabis products in the treatment of epilepsy has long been of interest to researchers and clinicians alike; however, until recently very little published data were available to support its use. This

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Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers.

Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers. Drug Alcohol Depend. 2016 Dec 14;172:9-13 Authors: Babalonis S, Haney M, Malcolm RJ, Lofwall MR, Votaw VR, Sparenborg S, Walsh SL Abstract BACKGROUND: Cannabidiol (CBD) is a naturally occurring constituent of the marijuana plant. In the past few years, there has

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Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review.

Related Articles Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review. Inflamm Bowel Dis. 2017 Jan 10;: Authors: Leinwand KL, Gerich ME, Hoffenberg EJ, Collins CB Abstract BACKGROUND: Inflammatory bowel disease (IBD) is a lifelong disease of the gastrointestinal tract whose annual incidence and prevalence is on the rise. Current immunosuppressive therapies available for

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A user's guide to cannabinoid therapies in oncology.

Related Articles A user’s guide to cannabinoid therapies in oncology. Curr Oncol. 2016 Dec;23(6):398-406 Authors: Maida V, Daeninck PJ Abstract “Cannabinoid” is the collective term for a group of chemical compounds that either are derived from the Cannabis plant, are synthetic analogues, or occur endogenously. Although cannabinoids interact mostly at the level of the currently

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Weed Power: Milk Thistle, Liver Disease & the Endocannabinoid System

Both milk thistle and cannabis convey therapeutic benefits that are mediated by the endocannabinoid system. The active component in milk thistle, silymarin, is responsible for its liver protective qualities and influence both CB1 and CB2 receptors throughout the body. Powered by WPeMatico

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CBD Eye Drops

Cannabis has been well known to treat eye pressure associated with glaucoma. Now new research indicates that direct topical application of cannabidiol (CBD) may be beneficial for neuropathic ocular pain. Powered by WPeMatico

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Therapeutic Use of Cannabis in Inflammatory Bowel Disease.

Related Articles Therapeutic Use of Cannabis in Inflammatory Bowel Disease. Gastroenterol Hepatol (N Y). 2016 Nov;12(11):668-679 Authors: Ahmed W, Katz S Abstract The marijuana plant Cannabis sativa and its derivatives, cannabinoids, have grown increasingly popular as a potential therapy for inflammatory bowel disease (IBD). Studies have shown that modulation of the endocannabinoid system, which regulates

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A Neuroscientist critiques New York Times report on synthetic “spice” cannabinoid

The street popularity of synthetic cannabinoid products such as “Spice” and others have caused problems for users. None of the naturally occurring cannabinoids from the marijuana plant have evolved to be full agonists of the cannabinoid receptors. Dr. Greg Gerdeman weighs in on how synthetic cannabinoid products are a result of cannabis prohibition. Powered by

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Cannabis and epilepsy: An ancient treatment returns to the fore.

Related Articles Cannabis and epilepsy: An ancient treatment returns to the fore. Epilepsy Behav. 2016 Dec 15;: Authors: Russo EB Abstract Cannabis has been associated with the treatment of epilepsy throughout history, and if ancient Assyrian sources referring to “hand of ghost” are considered credible, this relationship may span four millennia. A tradition of usage

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Inhibition of cervical cancer cell proliferation by cannabidiol.

Related Articles Inhibition of cervical cancer cell proliferation by cannabidiol. Planta Med. 2016 Dec;81(S 01):S1-S381 Authors: Bagavandoss P, Crawford B, Kramer C PMID: 27976061 [PubMed – in process] Powered by WPeMatico

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The DEA Bursts the CBD Bubble

In December of 2016, the DEA announced that it is implementing new rules designed to crack down on CBD oil products. Mass misinformation claiming cannabidiol was legal was promoted by numerous online businesses and their enabling attorneys. Educate yourself about the situation and what you can do. Powered by WPeMatico

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Cannabidiol oil in the treatment of super refractory status epilepticus. A case report.

Related Articles Cannabidiol oil in the treatment of super refractory status epilepticus. A case report. Seizure. 2016 Feb;35:56-8 Authors: Rosemergy I, Adler J, Psirides A PMID: 26803051 [PubMed – indexed for MEDLINE] Powered by WPeMatico

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Mitochondria Mysteries

Scientific data indicates that CBD & THC can affect mitochondria, the energy adaptors that power every multicellular organism. How do cannabinoids influence cellular function? Powered by WPeMatico

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Cannabinoids and Oxidation

Nishi Whiteley discusses the theme of cannabinoids and oxidation from her book “Chronic Relief: A Guide to Cannabis for the Terminally & Chronically Ill”. In the same way that paint protects metal from rusting or lemon juice protects apples from turning brown, cannabinoids protect our cells from oxidation. Powered by WPeMatico

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A systematic review of the effect of cannabidiol on cognitive function: Relevance to schizophrenia.

A systematic review of the effect of cannabidiol on cognitive function: Relevance to schizophrenia. Neurosci Biobehav Rev. 2016 Nov 21;: Authors: Osborne AL, Solowij N, Weston-Green K Abstract BACKGROUND AND OBJECTIVES: Cognitive impairment is a core symptom domain of schizophrenia, neurological disorders and substance abuse. It is characterised by deficits in learning, memory, attention and

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Evolution of multiple sclerosis spasticity-associated symptoms: latest data.

Evolution of multiple sclerosis spasticity-associated symptoms: latest data. Neurodegener Dis Manag. 2016 Dec;6(6s):9-12 Authors: Flachenecker P Abstract In addition to muscle stiffness and increasing mobility restrictions, symptoms commonly associated with multiple sclerosis (MS) spasticity are spasms, sleep disturbances, pain, fatigue and bladder dysfunction. Treatment options include trigger factor avoidance, physiotherapy and antispasticity medication. Oral antispasticity

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Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients.

Related Articles Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients. Epilepsia. 2016 Nov 18;: Authors: Treat L, Chapman KE, Colborn KL, Knupp KG Abstract OBJECTIVE: Oral cannabis extracts (OCEs) are being used in the treatment of epilepsy with increasing rates in the United States following product legalization; however, no

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Cannabidiol Mellows Out Resurgent Sodium Current.

Related Articles Cannabidiol Mellows Out Resurgent Sodium Current. Epilepsy Curr. 2016 Nov-Dec;16(6):399-401 Authors: Thompson CH, Kearney JA PMID: 27857623 [PubMed – in process] Powered by WPeMatico

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Medical Cannabis – another piece in the mosaic of autoimmunity?

Related Articles Medical Cannabis – another piece in the mosaic of autoimmunity? Clin Pharmacol Ther. 2016 Nov 10;: Authors: Katz D, Katz I, Porat-Katz BS, Shoenfeld Y Abstract Legalization of cannabis’ medicinal use is rapidly increasing worldwide, raising the need to evaluate medical implications of cannabis. Currently evidence supports cannabis and its active ingredients as

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Cannabinoid Buccal Spray for Chronic Non-Cancer or Neuropathic Pain: A Review of Clinical Effectiveness, Safety, and Guidelines

Related Articles Cannabinoid Buccal Spray for Chronic Non-Cancer or Neuropathic Pain: A Review of Clinical Effectiveness, Safety, and Guidelines Book. 2016 09 21 Authors: Abstract Chronic pain is a complex, severe and debilitating condition which can lead to a considerable reduction in function and quality of life. Patients may present with different forms of chronic

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Quantitative analyses of synergistic responses between cannabidiol and DNA-damaging agents on the proliferation and viability of glioblastoma and neural progenitor cells in culture.

Related Articles Quantitative analyses of synergistic responses between cannabidiol and DNA-damaging agents on the proliferation and viability of glioblastoma and neural progenitor cells in culture. J Pharmacol Exp Ther. 2016 Nov 7;: Authors: Deng L, Ng L, Ozawa T, Stella N Abstract Evidence suggests that the non-psychotropic cannabis-derived compound, cannabidiol (CBD), has anti-neoplastic activity in

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Targeting the Endocannabinoid System in Psychiatric Illness.

Related Articles Targeting the Endocannabinoid System in Psychiatric Illness. J Clin Psychopharmacol. 2016 Dec;36(6):691-703 Authors: Katzman MA, Furtado M, Anand L Abstract Prevalence of psychiatric disorders continues to rise globally, yet remission rates and patient outcome remain less than ideal. As a result, novel treatment approaches for these disorders are necessary to decrease societal economic

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Alice O’Leary Randall: The Court Case that Launched the Medical Cannabis Movement

Video interview with medical cannabis pioneer Alice O’Leary Randall on the momentous court case that launched the medical marijuana movement. Powered by WPeMatico

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Patient Survey: Cannabis in the Treatment of Age-Related Pain

A patient survey collaboration between Care by Design and Project CBD demonstrated that cannabis appears to be an effective pain management tool with few negative side effects. The study also found that a significant decrease in opiate usage among elderly patients while taking medical cannabis. Powered by WPeMatico

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Efficacy and safety of nabiximols (Sativex(®)) on multiple sclerosis spasticity in a real-life Italian monocentric study.

Related Articles Efficacy and safety of nabiximols (Sativex(®)) on multiple sclerosis spasticity in a real-life Italian monocentric study. Neurol Sci. 2016 Feb;37(2):235-42 Authors: Ferrè L, Nuara A, Pavan G, Radaelli M, Moiola L, Rodegher M, Colombo B, Keller Sarmiento IJ, Martinelli V, Leocani L, Martinelli Boneschi F, Comi G, Esposito F Abstract Multiple sclerosis (MS)

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Splendor in the Grass? A Pilot Study Assessing the Impact of Medical Marijuana on Executive Function.

Related Articles Splendor in the Grass? A Pilot Study Assessing the Impact of Medical Marijuana on Executive Function. Front Pharmacol. 2016;7:355 Authors: Gruber SA, Sagar KA, Dahlgren MK, Racine MT, Smith RT, Lukas SE Abstract Currently, 25 states and Washington DC have enacted full medical marijuana (MMJ) programs while 18 states allow limited access to

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PROPIEDADES DEL USO TÓPICO DEL ACEITE DE CÁÑAMO Y OTROS ACEITES DE USO MEDICINAL

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Introducción Existen plantas que han acompañado al Hombre desde el principio de los tiempos al destacar por sus múltiples propiedades medicinales, y en un principio, han sido consideradas casi mágicas. La cannabis, por su ubicuidad y multitud de usos, ha sido una de las principales consideradas como tal,  en numerosas culturas desde hace muchos años.

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Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration.

Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Oct 18;: Authors: Nabissi M, Morelli MB, Offidani M, Amantini C, Gentili S, Soriani A, Cardinali C, Leoni P, Santoni G Abstract Several studies showed a potential anti-tumor role for cannabinoids, by modulating cell signaling pathways involved in cancer cell proliferation, chemo-resistance

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Effect of cannabis smoking on lung function and respiratory symptoms: a structured literature review.

Effect of cannabis smoking on lung function and respiratory symptoms: a structured literature review. NPJ Prim Care Respir Med. 2016 Oct 20;26:16071 Authors: Ribeiro LI, Ind PW Abstract As cannabis use increases, physicians need to be familiar with the effects of both cannabis and tobacco on the lungs. However, there have been very few long-term

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Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes.

Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes. Clin Hemorheol Microcirc. 2016 Oct 18; Authors: Lehmann C, Fisher NB, Tugwell B, Szczesniak A, Kelly M, Zhou J Abstract BACKGROUND: Destruction of the insulin-producing beta cells in type 1 diabetes (T1D) is induced by invasion of immune cells causing pancreatic inflammation. Cannabidiol (CBD), a phytocannabinoid,

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Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol.

Related Articles Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol. Front Pharmacol. 2016;7:359 Authors: Crippa JA, Crippa AC, Hallak JE, Martín-Santos R, Zuardi AW Abstract Animal studies and preliminary clinical trials have shown that cannabidiol (CBD)-enriched extracts may have beneficial effects for children with

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Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats.

Related Articles Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats. Front Pharmacol. 2016;7:343 Authors: Peres FF, Levin R, Suiama MA, Diana MC, Gouvêa DA, Almeida V, Santos CM, Lungato L, Zuardi AW, Hallak JE, Crippa JA, Vânia D, Silva RH, Abílio VC Abstract Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa

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Data Distortion

Misinformation can masquerade as science, especially when it comes to cannabis. Adrian Devitt-Lee highlights how analysis can be skewed for a variety of factors and gives insight on how to spot faulty research data. Powered by WPeMatico

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Ask Project CBD: Cannabinoid Production

We answer a question from a reader about the evolutionary reason that Cannabis produces its cannabinoid compounds. Powered by WPeMatico

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Tetrahydrocannabinol:Cannabidiol Oromucosal Spray for Multiple Sclerosis-Related Resistant Spasticity in Daily Practice.

Tetrahydrocannabinol:Cannabidiol Oromucosal Spray for Multiple Sclerosis-Related Resistant Spasticity in Daily Practice. Eur Neurol. 2016 Oct 13;76(5-6):216-226 Authors: Vermersch P, Trojano M Abstract BACKGROUND: Tetrahydrocannabinol:cannabidiol (THC:CBD) oromucosal spray (Sativex®) is an add-on therapy for moderate-to-severe multiple sclerosis (MS)-related drug-resistant spasticity (MSS). AIM: The MOVE-2 EU study collected data from everyday clinical practice concerning the effectiveness and

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The neuroprotection of cannabidiol against MPP⁺-induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson's disease.

Related Articles The neuroprotection of cannabidiol against MPP⁺-induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson’s disease. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):231-40 Authors: Santos NA, Martins NM, Sisti FM, Fernandes LS, Ferreira RS, Queiroz RH, Santos AC Abstract Cannabidiol (CBD)

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Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol.

Related Articles Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol. Brain. 2016 Aug;139(Pt 8):2164-81 Authors: Patel RR, Barbosa C, Brustovetsky T, Brustovetsky N, Cummins TR Abstract Mutations in brain isoforms of voltage-gated sodium channels have been identified in patients with distinct epileptic phenotypes. Clinically, these patients often do not respond well

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Orrin Devinsky: breaking through treatment-resistant epilepsy.

Related Articles Orrin Devinsky: breaking through treatment-resistant epilepsy. Lancet Neurol. 2016 Mar;15(3):244 Authors: Kirby T PMID: 26888351 [PubMed – indexed for MEDLINE] Powered by WPeMatico

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Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release.

Related Articles Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release. Neurotoxicology. 2015 Sep;50:116-21 Authors: Gobira PH, Vilela LR, Gonçalves BD, Santos RP, de Oliveira AC, Vieira LB, Aguiar DC, Crippa JA, Moreira FA Abstract Cannabidiol (CBD), a major non-psychotomimetic constituent of Cannabis

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Effects of CB1 receptor agonism and antagonism on behavioral fear and physiological stress responses in adult intact, ovariectomized, and estradiol-replaced female rats.

Related Articles Effects of CB1 receptor agonism and antagonism on behavioral fear and physiological stress responses in adult intact, ovariectomized, and estradiol-replaced female rats. Neuroscience. 2015 Oct 15;306:123-37 Authors: Simone JJ, Malivoire BL, McCormick CM Abstract There is growing interest in the development of cannabis-based therapies for the treatment of fear and anxiety disorders. There

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The Utility of Cannabidiol in the Treatment of Refractory Epilepsy.

Related Articles The Utility of Cannabidiol in the Treatment of Refractory Epilepsy. Clin Pharmacol Ther. 2016 Aug 10; Authors: Reddy DS Abstract Cannabis-derived cannabinoids such as cannabidiol (CBD) have anticonvulsant properties. Recently, there has been an emerging interest in the use of CBD-enriched products for treatment of drug-resistant epilepsy. Some pilot trials of CBD have

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Medical Marijuana for Epilepsy?

Related Articles Medical Marijuana for Epilepsy? Innov Clin Neurosci. 2016 Mar-Apr;13(3-4):23-6 Authors: Kolikonda MK, Srinivasan K, Enja M, Sagi V, Lippmann S Abstract Treatment-refractory epilepsy remains an important clinical problem. There is considerable recent interest by the public and physicians in using medical marijuana or its derivatives to treat seizures. The endocannabinoid system has a

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Cannabidiol in patients with treatment-resistant epilepsy – Authors' reply.

Related Articles Cannabidiol in patients with treatment-resistant epilepsy – Authors’ reply. Lancet Neurol. 2016 May;15(6):545-6 Authors: Devinsky O, Marsh E, Friedman D PMID: 27302119 [PubMed – in process] Powered by WPeMatico

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Cannabidiol in patients with treatment-resistant epilepsy.

Related Articles Cannabidiol in patients with treatment-resistant epilepsy. Lancet Neurol. 2016 May;15(6):544 Authors: Bauer PR, Sander JW PMID: 27302118 [PubMed – in process] Powered by WPeMatico

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Cannabidiol in patients with treatment-resistant epilepsy.

Related Articles Cannabidiol in patients with treatment-resistant epilepsy. Lancet Neurol. 2016 May;15(6):544-5 Authors: Mandelbaum DE PMID: 27302117 [PubMed – in process] Powered by WPeMatico

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Anti-inflammatory and antioxidant effects of a combination of cannabidiol and moringin in LPS-stimulated macrophages.

Related Articles Anti-inflammatory and antioxidant effects of a combination of cannabidiol and moringin in LPS-stimulated macrophages. Fitoterapia. 2016 Jul;112:104-15 Authors: Rajan TS, Giacoppo S, Iori R, De Nicola GR, Grassi G, Pollastro F, Bramanti P, Mazzon E Abstract Inflammatory response plays an important role in the activation and progress of many debilitating diseases. Natural products,

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Cannabis for Refractory Psoriasis-High Hopes for a Novel Treatment and a Literature Review.

Related Articles Cannabis for Refractory Psoriasis-High Hopes for a Novel Treatment and a Literature Review. Curr Clin Pharmacol. 2016;11(2):146-7 Authors: Derakhshan N, Kazemi M Abstract Psoriasis is a common skin disorder characterized by hyper proliferation of keratinocytes. Although the exact pathophysiology of psoriasis is not entirely understood, immune system and its interaction with nervous system

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Marijuana dependence moderates the effect of posttraumatic stress disorder on trauma cue reactivity in substance dependent patients.

Related Articles Marijuana dependence moderates the effect of posttraumatic stress disorder on trauma cue reactivity in substance dependent patients. Drug Alcohol Depend. 2016 Feb 1;159:219-26 Authors: Tull MT, McDermott MJ, Gratz KL Abstract BACKGROUND: Individuals with posttraumatic stress disorder (PTSD) are at heightened risk for marijuana use. Although extant studies speak to the importance of

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Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa.

Related Articles Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa. FEBS J. 2016 Mar;283(6):1088-106 Authors: Yang X, Matsui T, Kodama T, Mori T, Zhou X, Taura F, Noguchi H, Abe I, Morita H Abstract UNLABELLED: In polyketide biosynthesis, ring formation is one of the key diversification steps. Olivetolic acid cyclase

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Expression, purification and crystallization of a plant polyketide cyclase from Cannabis sativa.

Related Articles Expression, purification and crystallization of a plant polyketide cyclase from Cannabis sativa. Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1470-4 Authors: Yang X, Matsui T, Mori T, Taura F, Noguchi H, Abe I, Morita H Abstract Plant polyketides are a structurally diverse family of natural products. In the biosynthesis of plant polyketides,

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TRPV2 is a novel biomarker and therapeutic target in triple negative breast cancer.

Related Articles TRPV2 is a novel biomarker and therapeutic target in triple negative breast cancer. Oncotarget. 2016 May 27; Authors: Elbaz M, Ahirwar D, Xiaoli Z, Zhou X, Lustberg M, Nasser MW, Shilo K, Ganju RK Abstract Transient receptor potential vanilloid type-2 (TRPV2) is an ion channel that is triggered by agonists like cannabidiol (CBD).

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The Use of Medical Marijuana in Cancer.

Related Articles The Use of Medical Marijuana in Cancer. Curr Oncol Rep. 2016 Jul;18(7):40 Authors: Birdsall SM, Birdsall TC, Tims LA Abstract The use of medical marijuana in cancer care presents a dilemma for both patients and physicians. The scientific evidence is evolving, yet much of the known information is still insufficient to adequately inform

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Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex.

Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex. Epilepsia. 2016 Oct 3;: Authors: Hess EJ, Moody KA, Geffrey AL, Pollack SF, Skirvin LA, Bruno PL, Paolini JL, Thiele EA Abstract OBJECTIVE: Tuberous sclerosis complex (TSC) is an autosomal-dominant genetic disorder with highly variable expression. The most common neurologic manifestation of TSC

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Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases.

Related Articles Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases. J Child Neurol. 2016 Sep 21; Authors: Gofshteyn JS, Wilfong A, Devinsky O, Bluvstein J, Charuta J, Ciliberto MA, Laux L, Marsh ED Abstract Febrile infection-related epilepsy syndrome (FIRES) is a devastating epilepsy affecting normal children

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From cannabis to cannabidiol to treat epilepsy, where are we?

Related Articles From cannabis to cannabidiol to treat epilepsy, where are we? Curr Pharm Des. 2016 Aug 31; Authors: Lippiello P, Balestrini S, Leo A, Coppola A, Citraro R, Elia M, Russo E, De Sarro G Abstract BACKGROUND: Several antiepileptic drugs (AEDs), about 25, are currently clinically available for the treatment of patients with epilepsy.

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Cannabidiol and Epilepsy: Sifting, Winnowing and Buzz.

Related Articles Cannabidiol and Epilepsy: Sifting, Winnowing and Buzz. Epilepsy Curr. 2016 Jul-Aug;16(4):239-41 Authors: Gidal BE PMID: 27582660 [PubMed] Powered by WPeMatico

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Emerging Antiepileptic Drugs for Severe Pediatric Epilepsies.

Related Articles Emerging Antiepileptic Drugs for Severe Pediatric Epilepsies. Semin Pediatr Neurol. 2016 May;23(2):167-79 Authors: Mudigoudar B, Weatherspoon S, Wheless JW Abstract The medical management of the epilepsy syndromes of early childhood (eg, infantile spasms, Dravet syndrome, and Lennox-Gastaut syndrome) is challenging; and requires careful evaluation, classification, and treatment. Pharmacologic therapy continues to be the

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pain in Extrapyramidal Neurodegenerative Diseases.

Related Articles pain in Extrapyramidal Neurodegenerative Diseases. Clin J Pain. 2016 Sep 10; Authors: Yust Katz S, Hershkovitz R, Gurevich T, Djaldetti R Abstract OBJECTIVE: Pain is one of the most common non-motor symptoms of Parkinson disease (PD) and other Parkinson plus syndromes, with a major effect on quality of life. The aims of the

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Pure Δ(9)-tetrahydrocannabivarin and a Cannabis sativa extract with high content in Δ(9)-tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages.

Related Articles Pure Δ(9)-tetrahydrocannabivarin and a Cannabis sativa extract with high content in Δ(9)-tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages. Pharmacol Res. 2016 Aug 3;113(Pt A):199-208 Authors: Romano B, Pagano E, Orlando P, Capasso R, Cascio MG, Pertwee R, Marzo VD, Izzo AA, Borrelli F Abstract Historical and scientific evidence suggests that Cannabis use

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Cannabinoids, inflammation, and fibrosis.

Related Articles Cannabinoids, inflammation, and fibrosis. FASEB J. 2016 Jul 19; Authors: Zurier RB, Burstein SH Abstract Cannabinoids apparently act on inflammation through mechanisms different from those of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs). As a class, the cannabinoids are generally free from the adverse effects associated with NSAIDs. Their clinical development thus provides

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Long-term hippocampal glutamate synapse and astrocyte dysfunctions underlying the altered phenotype induced by adolescent THC treatment in male rats.

Related Articles Long-term hippocampal glutamate synapse and astrocyte dysfunctions underlying the altered phenotype induced by adolescent THC treatment in male rats. Pharmacol Res. 2016 Sep;111:459-70 Authors: Zamberletti E, Gabaglio M, Grilli M, Prini P, Catanese A, Pittaluga A, Marchi M, Rubino T, Parolaro D Abstract Cannabis use has been frequently associated with sex-dependent effects on

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Gastric acid inhibitory and gastric protective effects of Cannabis and cannabinoids.

Related Articles Gastric acid inhibitory and gastric protective effects of Cannabis and cannabinoids. Asian Pac J Trop Med. 2016 May;9(5):413-9 Authors: Abdel-Salam O Abstract Cannabis sativa has long been known for its psychotropic effect. Only recently with the discovery of the cannabinoid receptors, their endogenous legends and the enzymes responsible for their synthesis and degradation,

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Cannabidiol: a potential treatment for post Ebola Syndrome?

Related Articles Cannabidiol: a potential treatment for post Ebola Syndrome? Int J Infect Dis. 2016 Sep 26; Authors: Reznik SE, Gardner EL, Ashby CR Abstract Patients recovered from Ebola virus infection may experience short- and long-term physical, neuropsychological and social sequelae, including arthralgia, musculoskeletal pain, ophthalmic inflammation, auditory problems, fatigue, confusion, insomnia, short-term memory impairment,

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Medical Marijuana: Just the Beginning of a Long, Strange Trip?

Related Articles Medical Marijuana: Just the Beginning of a Long, Strange Trip? Phys Ther. 2016 Sep 22; Authors: Ciccone CD Abstract Medical marijuana continues to gain acceptance and become legalized in many states. Various species of the marijuana plant have been cultivated, and this plant can contain up to 100 active compounds known as cannabinoids.

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Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Cisplatin-Induced Neuropathy in Mice.

Related Articles Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Cisplatin-Induced Neuropathy in Mice. Planta Med. 2016 Aug;82(13):1169-72 Authors: Harris HM, Sufka KJ, Gul W, ElSohly MA Abstract Sativex, a cannabinoid extract with a 1 : 1 ratio of tetrahydocannabinol and cannabidiol, has been shown to alleviate neuropathic pain associated with chemotherapy. This research examined whether tetrahydocannabinol or cannabidiol

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Phyto-, endo- and synthetic cannabinoids: promising chemotherapeutic agents in the treatment of breast and prostate carcinomas.

Related Articles Phyto-, endo- and synthetic cannabinoids: promising chemotherapeutic agents in the treatment of breast and prostate carcinomas. Expert Opin Investig Drugs. 2016 Sep 28;:1-13 Authors: Fraguas-Sánchez AI, Fernández-Carballido A, Torres-Suárez AI Abstract INTRODUCTION: The term ‘cannabinoids’ designates a family of compounds with activity upon cannabinoid receptors. Cannabinoids are classified in three groups: phytocannabinoids, endocannabinoids,

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Evaluation of Two Commercially Available Cannabidiol Formulations for Use in Electronic Cigarettes.

Related Articles Evaluation of Two Commercially Available Cannabidiol Formulations for Use in Electronic Cigarettes. Front Pharmacol. 2016;7:279 Authors: Peace MR, Butler KE, Wolf CE, Poklis JL, Poklis A Abstract Since 24 states and the District of Columbia have legalized marijuana in some form, suppliers of legal marijuana have developed Cannabis sativa products for use in

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Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells.

Related Articles Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells. BMC Complement Altern Med. 2016;16(1):335 Authors: Lukhele ST, Motadi LR Abstract BACKGROUND: Cervical cancer remains a global health related issue among females of Sub-Saharan Africa, with over half a million new cases reported each year. Different therapeutic

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Cannabinoids for Symptom Management and Cancer Therapy: The Evidence.

Related Articles Cannabinoids for Symptom Management and Cancer Therapy: The Evidence. J Natl Compr Canc Netw. 2016 Jul;14(7):915-22 Authors: Davis MP Abstract Cannabinoids bind not only to classical receptors (CB1 and CB2) but also to certain orphan receptors (GPR55 and GPR119), ion channels (transient receptor potential vanilloid), and peroxisome proliferator-activated receptors. Cannabinoids are known to

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ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice.

Related Articles ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice. PeerJ. 2016;4:e2081 Authors: Brzozowska N, Li KM, Wang XS, Booth J, Stuart J, McGregor IS, Arnold JC Abstract Cannabidiol (CBD) is currently being investigated as a novel therapeutic for the treatment of

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Is Kratom the CBD of Opioids?

Kratom is an unique medicinal herb with pain relieving properties that function as an opiate substitute. So why is the FDA and the DEA trying to block people’s access to it by making it a Schedule 1 drug? Powered by WPeMatico

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Current Therapeutic Cannabis Controversies and Clinical Trial Design Issues

A review article by Dr. Ethan Russo on current cannabis controversies, including new data on pesticide contamination in the legal cannabis market in Washington State. Powered by WPeMatico

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I’m Just Mad About Saffron

Numerous plants — not just cannabis — are endowed with compounds that interact directly or indirectly with the endocannabinoid system. The health benefits of many common kitchen spices are mediated by the same cannabinoid receptors in the human brain and body that marijuana activates. Powered by WPeMatico

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When Bob Dylan Turned the Beatles On To Marijuana

On August 28th, 1964 Bob Dylan introduced the Beatles to cannabis for their first time. And the rest is more than just rock ‘n’ roll history. Powered by WPeMatico

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Clinical Endocannabinoid Deficiency Reconsidered

A pioneer neurologist, Dr. Ethan Russo, examines recent scientific data on migraine, fibromyalgia, irritable bowel, and other treatment-resistant syndromes that may respond to cannabinoid therapies. Powered by WPeMatico

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Cannabis as Medicine Has Strong Roots in Science

Neuroscientist Greg Gerdeman, PhD, one of the rare professors to teach the endocannabinoid system in college, challenges health professionals and researchers to study cannabis science and therapeutics. Powered by WPeMatico

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CBD User's Manual

Many health professionals have little to no experience with cannabis therapeutics and are not able to guide people on this subject. So Project CBD has created a beginner’s guide to cannabidiol & cannabis therapeutics to address key questions of CBD users. Powered by WPeMatico

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ICRS 2016: Report from Bukovina

The 2016 meeting of the International Cannabinoid Research Society focused on the latest research in cannabinoid studies and the endocannabinoid system. Powered by WPeMatico

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Investigación con Cannabinoides en Cáncer de Mama

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El cáncer de mama es uno de los tipos de cáncer más diagnosticados a mujeres en el mundo, según datos del National Cancer Institute. Durante el año 2015, se diagnosticaron aproximadamente unos 246.660  casos de cáncer de mama invasivo a mujeres, y cáncer de mama in situ a 61,000 mujeres en los Estados Unidos. En

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Cannabinoides y enfermedades neurodegenerativas: ¿una futura terapia?

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La enfermedad de Alzheimer es un proceso neurodegenerativo de causa desconocida, que suele aparecer alrededor de los 65 años (aunque puede aparecer antes), en el que se observan cambios neurológicos asociados a la aparición de placas amoloideas y ovillos neurofibrilares, con la consecuente pérdida de las conexiones neuronales. Todo ello provoca un deterioro progresivo de

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CANNABIDIOL: POTENCIAL TERAPÉUTICO PARA EL TRATAMIENTO DE LA ARTRITIS

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Se entiende por artritis a las diferentes enfermedades que cursan con inflamación de las articulaciones, es decir, del área de unión de dos huesos. Se conocen más de 100 tipos de artritis diferentes, aunque todas ellas presentan una característica común: la inflamación de la articulación, que conlleva a una degradación del cartílago que la protege.

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Targeted Treatment in Childhood Epilepsy Syndromes.

Targeted Treatment in Childhood Epilepsy Syndromes. Curr Treat Options Neurol. 2016 Jun;18(6):29 Authors: Vezyroglou K, Cross JH Abstract OPINION STATEMENT: The mainstay of treatment of epilepsy has been antiepileptic drugs; however, despite the emergence of new agents, a consistent proportion remain drug-resistant. Newer AEDs show promise. However, as it becomes clear that the epilepsies are

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